A woman presenting with vulval lesions is to be examined and evaluated further before giving her the definitive diagnosis proposing treatment. As differential may vary from benign like lichen sclerosus, intraepithelial neoplasia or malignant squamous cell carcinoma. We are a case report wherein 70 year presented features similar carcinoma but was diagnosed as pseudoepitheliomatous hyperplasia o...

A) Verruca vulgaris B) Actinic keratosis C) Bowenoid papulosis D) Seborrheic keratosis E) Acanthoma High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). Citation: Kupetsky EA, Charles CA, Mones J. High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). A case and review. Copyright: ©2015 Kupetsky et al. This is an open-access ar...

Human papillomavirus (HPV) infection is highly prevalent and a common cause of abnormal cytology, particularly among young, sexually active women. With hybrid capture system assay, HPV can be further classified into The majority of HPV infections are believed to regress spontaneously. However , the natural history of infection in a particular woman and factors associated with individual persist...

OBJECTIVE Knowledge regarding the prevalence and distribution of human papillomavirus (HPV) genotyping in healthy women is important in establishing strategies for cervical cancer screening and HPV vaccination. METHODS A total of 18,170 women who visited a Korean Medical Institute for health check-ups were recruited retrospectively; they underwent HPV genotyping and conventional cervical cyto...

PURPOSE High-risk human papilloma virus (HPV) plays a role in the development of a subset of vulvar squamous cell carcinomas. Uncertainty exists about the true impact of HPV in this tumor type because conflicting reports have been published with diverging prevalence rates. This study was done to fine tune the role of high-risk HPV infection in vulvar squamous cell carcinoma development in relat...

Detection of persistent cervical carcinogenic human papillomavirus (HPV) DNA is used as a marker for cervical cancer risk in clinical trials. The authors performed a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (togethe...

C ervical cancer is one of the most common cancers among women around the world, especially in developing countries. Current screening and diagnostic protocols, Papanicolaou test (Pap smear) followed by colposcopy, have some limitations including low sensitivity1 copy which often leads to unnecessary biopsies.2 Therefore, there is increasing interest in alternative or complementary methods whic...

Sixteen low grade (LSIL), 22 high grade (HSIL) squamous intraepithelial lesions, 28 invasive (13 stage I and 15 stage II-IV) squamous cell carcinoma (SCC) and 15 benign cervices were immunohistochemically studied for involvement of Bcl-2 and Bax proteins in cervical carcinogenesis. 4-microm sections of the cases were immunostained for Bcl-2 (Clone 124: Dako) and Bax (Dako) and staining intensit...

BACKGROUND γH2AX is a protein biomarker for double-stranded DNA breakage; its expression was studied in cervical squamous intraepithelial lesions and carcinomas. METHODS Immunostaining for phospho-γH2AX was performed in sections from histologically confirmed cervical SIL and carcinomas, as well as from normal cervices used as controls. In total, 275 cases were included in the study: 112 low g...

BACKGROUND: The accuracy of cervical cytology has been quwstioned due to high false negative rate. In order to improve the sensitivity of cytology it is prudent to analyze the factors which hamper with the diagnosis of high grade lesions. AIMS: To study the cyto-histologic agreement in High grade squamous intraepithelial lesions (HSIL) of uterine cervix and to analyze the smear characteristics ...