When cells migrate through constricting pores, they incur DNA damage and develop genomic variation. Experiments show that this damage is not due to DNA breakage from mechanical stress on chromatin in the deformed nucleus. Here we propose a model for a mechanism by which nuclear deformation can lead to DNA damage. We treat the nucleus as an elastic-fluid system with an elastic component (chromat...

Despite a dearth of theoretical studies, there is widespread perception that microfinance is an enormously useful tool for economic development. However, an increasing number of households in lesser developed countries are facing the same debt squeeze as those in the developed world, but are less able to manage debt responsibilities. The consequences are much more dramatic for LDC households be...

We introduce a stochastic version of the classical Perron’s method to construct viscosity solutions to linear parabolic equations associated to stochastic differential equations. Using this method, we construct easily two viscosity (sub and super) solutions that squeeze in between the expected payoff. If a comparison result holds true, then there exists a unique viscosity solution which is a ma...

Squeeze casting is a process that can produce the highest quality castings. In current study, effect of settings and in-die conditions on rejection rates studied through full-scale experimental study. Factors affecting as-cast part were investigated in study from two different viewpoints. The first was to investigate influence rate, second understand die effects rate better reasons sensitivity ...