We use a simple carbon cycle-climate model to investigate the interactions between a selection of idealized scenarios of mitigated carbon dioxide emissions, carbon dioxide removal (CDR) and solar radiation management (SRM). Two CO(2) emissions trajectories differ by a 15-year delay in the start of mitigation activity. SRM is modelled as a reduction in incoming solar radiation that fully compens...

Switched Reluctance Motor is a rotating electric machine where both stator and rotor have salient poles. Switched Reluctance Motor (SRM) drives are gaining attention due to their extremely rugged construction and fault-tolerant capabilities, which prove that SRM drives, are highly suitable for variety of industrial applications. In this paper, FPGA based digital controllers are designed for a 6...

The paper presents a significant improvement to the implementation of the spectral relaxation method (SRM) for solving nonlinear partial differential equations that arise in the modelling of fluid flow problems. Previously the SRM utilized the spectral method to discretize derivatives in space and finite differences to discretize in time. In this work we seek to improve the performance of the S...

OBJECTIVE To compare the responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and a questionnaire format of the Lequesne-Algofunctional Index in patients with OA of the lower extremities. METHODS Longitudinal analysis of the instruments' responsiveness [standardized response mean (SRM), effect size (ES)] in ambulatory patients undergoing hip or knee art...

The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc expression. Inhibition of ornithine decarboxylase, an enzyme of the polyamine biosynthetic pathway and a Myc target, has been shown to be...

OBJECTIVE Millions of patients experience the disabling hand manifestations of rheumatoid arthritis (RA), yet few hand-specific instruments are validated in this population. Our objective was to assess the reliability, validity, and responsiveness of the Michigan Hand Questionnaire (MHQ) in patients with RA. METHODS At enrollment and at 6 months, 128 RA patients with severe subluxation of the...

The recent discovery of the "Stress Repair Mechanism" (SRM) enables the Unified Theory of Medicine postulated by Hans Selye. It confers cohesive theories of anesthesia, analgesia, and allostasis that enable the alteration of anesthetic technique to optimize surgical outcome. The SRM continuously maintains and repairs the vertebrate body in accord with stressful forces and stimuli. Three synergi...

Protein turnover represents an important mechanism in the functioning of cells, with deregulated synthesis and degradation of proteins implicated in many diseased states. Therefore, proteomics strategies to measure turnover rates with high confidence are of vital importance to understanding many biological processes. In this study, the more widely used approach of non-targeted precursor ion sig...

This paper presents the design, and simulation of a soft switched boost converter for a switched reluctance motor with a closed loop controller. A soft switching scheme is proposed in the converter with minimum components, which reduces the switching loss and stress across the switch so that the harmonic generation is reduced in the output. The switch used in this converter switched ON at zero ...

This paper presents a sliding mode observer for sensorless operation of SRM (switched reluctance motor) drive. Design of such an observer depends mainly on the nonlinear model of SRM. In this technique, neither extra hardware nor huge memory space arenot required but it only requires active phase measurements. Furthermore, PI (proportional integral) are suggested to operate individually along w...