Objectives The aim of this study is to investigate the effect two abundant dietary supplements, quercetin and vitamin C on some factors involved in metastasis proliferation prostate cancer, which are resistant conventional chemotherapies late stages. Background Bone brain common sites metastases nevertheless their metastatic pathways not well understood. Methods (75µM) (100 µM) CXCR4, CXCR7 che...

BACKGROUND The pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor β1 (TGF-β1) is considered central in the pathogenesis. OBJECTIVES To investigate TGF-β1 pathway in IPF. ANIMALS Lung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (1...

Development of the cerebral cortex requires regulation of proliferation and differentiation of neural stem cells and a diverse range of progenitors. Recent work suggests a role for extracellular matrix (ECM) and the major family of ECM receptors, the integrins. Here we show that enhancing integrin beta-1 signalling, by expressing a constitutively active integrin beta-1 (CA*β1) in the embryonic ...

Abstract Accumulation of various immunosuppressive myeloid cells, including myeloid-derived suppressor cells (MDSCs), facilitates progression and treatment resistance glioblastoma (GBM). We previous demonstrated that monocytic MDSCs (mMDSCs) but not granulocytic (gMDSCs) infiltrate tumors in mouse models patients, nonspecific targeting mMDSCs with chemotherapies provided therapeutic benefit pre...

Angiopoietin-like 4 (ANGPTL4) is a potential anti-apoptotic agent for various cells. We examined the protective effect of ANGPTL4 on hypoxia/serum deprivation (SD)-induced apoptosis of MSCs, as well as the possible mechanisms. MSCs were obtained from rat bone marrow and cultured in vitro. Apoptosis was induced by hypoxia/SD for up to 24 hr, and assessed by flow cytometry and TUNEL assay. Expres...

Integrins are divalent cation-dependent, αβ heterodimeric adhesion receptors that control many fundamental aspects of cell behaviour by bi-directional signalling between the extracellular matrix and intracellular cytoskeleton. The activation state of cell surface integrins is tightly regulated by divalent cation occupancy of the ligand-binding pocket and by interaction with cytoplasmic adaptor ...

Soybean agglutinin (SBA) is an anti-nutritional factor of soybean, affecting cell proliferation and inducing cytotoxicity. Integrins are transmembrane receptors, mediating a variety of cell biological processes. This research aims to study the effects of SBA on cell proliferation and cell cycle progression of the intestinal epithelial cell line from piglets (IPEC-J2), to identify the integrin s...

Expression of L1 cell adhesion molecule (L1CAM) is associated with poor prognosis in a variety of human carcinomas including breast, ovarian and pancreatic ductal adenocarcinoma (PDAC). Recently we reported that L1CAM induces sustained nuclear factor kappa B (NF-κB) activation by augmenting the autocrine production of interleukin 1 beta (IL-1β), a process dependent on interaction of L1CAM with ...

During early embryonic development, certain groups of cells, like neural crest cells, can transiently express locomotory properties that allow them to migrate long distances from their sites of origin and populate other areas of the embryo where they undergo differentiation (Le Douarin, 1982; Newgreen and Erickson, 1986; Levi et al., 1990; Erickson and Perris, 1993). During migration to their f...