In somatostatinoma, a rare malignant somatostatin (SST)-secreting neoplasia, tumour regression is rarely observed, implying the need for novel antiproliferative strategies. Here, we characterized a long-term culture (SST-secreting cancer (SS-C cells)) established from a human somatostatinoma. High concentrations of SST and chromogranin A were released by SS-C cells and SST release was stimulate...

The spatial distribution of sperm within the sperm storage tubules (SST) found in the uterovaginal junction (UVJ) of the turkey is not known. In this study, we inseminated sperm stained with a fluorescent dye (Hoechst 33342) to determine their distribution in SST in the ventral, dorsal, and lateral regions of the proximal, middle, and distal regions of the UVJ. There was no preferential filling...

in this paper, the potential of polarimetric sar data using target decomposition features to detect oil pollutions are evaluated. for this purpose, the values of power, phase and magnitude of all of the polarization channels (hh, vv, hv and vh) and decomposition features i.e. freeman, yamaguchi, vanzyl and krogager are computed. then, to detect oil pollutions, different combinations of these fe...

The pattern of expression of somatostatin receptor (SSTR) genes and gene products in AtT-20 cells was characterized in an attempt to explain the SST-28 binding selectivity that typifies these cells. AtT-20 cells expressed multiple SSTR mRNAs. Paradoxically, this included mRNA for three of the four SST-14 selective receptors: SSTR2 ( +), SSTR1 (+), SSTR4 (+). The SST-28 selective SSTR5 was expre...

Somatostatin (SST) and cortistatin (CORT) regulate numerous endocrine secretions and their absence [knockout (KO)-models] causes important endocrine-metabolic alterations, including pituitary dysregulations. We have demonstrated that the metabolic phenotype of single or combined SST/CORT KO-models is not drastically altered under normal conditions. However, the biological actions of SST/CORT ar...

Mammalian cortex contains a diversity of inhibitory neuron types, each with distinct morphological, immunochemical, and/or physiological properties. In rat cortex, chemical markers distinguish at least four distinct and nonoverlapping neuron classes based on expression of parvalbumin (PV), somatostatin (SST), calretinin (CR), and cholecystokinin (CCK). It has generally been assumed that these c...

PURPOSE To determine whether the somatostatin receptor 2 (sst(2)) influences angiogenesis and its associated factors in a model of hypoxia-induced retinal neovascularization. METHODS sst(1)-knockout (KO) mice, in which sst(2) is overexpressed and overfunctional, and sst(2)-KO mice were used. Angiogenesis was evaluated in fluorescein-perfused retinas. Angiogenesis-associated factors were deter...

BACKGROUND Among the five somatostatin receptors (sst(1)-sst(5)), the sst(3) receptor displays a distinct pharmacological profile. Like sst(2), the sst(3) receptor efficiently internalizes radiolabeled somatostatin analogs. Unlike sst(2), however, internalized sst(3) receptors are rapidly transferred to lysosomes for degradation. Apart from this, very little is known about the clinical relevanc...

In this paper we introduce some search strategies under the general term SST (Search Strategy for Tutoring) intended to be used in tutoring games. Contrary to principles of tutoring game-playing programs stated elsewhere, we argue that tutoring systems not necessarily should interrupt games or provide explicit advice. In addition, unlike earlier tutoring strategies , SST does not depend on a pr...