Over the last few years, there has been a dramatic increase in the use of cDNA microarrays to monitor gene expression changes in biological systems. Data from these experiments are usually transformed into expression ratios between experimental samples and a common reference sample for subsequent data analysis. The accuracy of this critical transformation depends on two major parameters: the si...

MOTIVATION The systematic integration of expression profiles and other types of gene information, such as chromosomal localization, ontological annotations and sequence characteristics, still represents a challenge in the gene expression arena. In particular, the analysis of transcriptional data in context of the physical location of genes in a genome appears promising in detecting chromosomal ...

Genetic interactions or epistasis have been thought to play a pivotal role in shaping the formation, development and evolution of life. Previous work focused on lower-order interactions between a pair of genes, but it is obviously inadequate to explain a complex network of genetic interactions and pathways. We review and assess a statistical model for characterizing high-order epistasis among m...

BACKGROUND In healthcare, patients with diabetes are instructed on how to apply intensified insulin therapy in an optimal manner. Tight blood glucose control is also performed on patients treated in the intensive care unit (ICU). Different blood glucose meters and glucose monitoring systems (GMSs) are used to achieve this goal, and some may lack reliability. METHODS The GLYCENSIT procedure is...

Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for ...

INTRODUCTION In order to study social health inequalities, contextual (or ecologic) data may constitute an appropriate alternative to individual socioeconomic characteristics. Indices can be used to summarize the multiple dimensions of the neighborhood socioeconomic status. This work proposes a statistical procedure to create a neighborhood socioeconomic index. METHODS The study setting is co...

Multiple comparisons and multiple testing problems arise frequently in statistical data analysis, and it is important to address them appropriately. Closed testing methods are among the most powerful multiple inference methods available, and are therefore gaining rapidly in popularity. The purpose of this article is to explain what a closed testing procedure is, why such methods are desirable, ...

A single-step maximum likelihood estimation procedure is developed for multidimensional scaling of dissimilarity data measured on rating scales. The procedure can fit the euclidian distance model to the data under various assumptions about category widths and under two distributional assumptions. The scoring algorithm for parameter estimation has been developed and implemented in the form of a ...

Comprehensive computational experiments to assess the performance of algorithms for numerical optimization require (among other things) a practical procedure for generating pseudorandom nonlinear objective functions. We propose a procedure that is based on the convenient ction that objective functions are realizations of stochastic processes. This report details the calculations necessary to im...

Regression is one of the favorite tools in applied statistics. However, misuse and misinterpretation of results from regression analysis are common in biomedical research. In this paper we use statistical theory and simulation studies to clarify some paradoxes around this popular statistical method. In particular, we show that a widely used model selection procedure employed in many publication...