The crystal structure unequivocally confirms the relative stereochemistry of the title compound, C(6)H(13)FO(5) [6-de-oxy-6-fluoro-d-galactitol or (2S,3R,4R,5S)-6-fluoro-hexane-1,2,3,4,5-penta-ol]. The absolute stereochemistry was determined from the use of d-galactose as the starting material. In the crystal, the molecules are linked by O-H⋯O and O-H⋯F hydrogen bonds, forming a three-dimension...

The structures and stereochemistry of OA- 6129D and E, new carbapenam compounds produced by Streptomyces sp. OA-6129, were determined by spectroscopic analysis and chemical transformation.

The properties and the structure of a new anthracycline antibiotic carminomycin, were described recently.1) In this paper we wish to discuss the stereochemistry of carminomycin. We have studied the NMR and CD spectra of carminomycin, its aglycone (carminomycinone) and 7-deoxycarminomycinone. For comparative purposes the corresponding derivatives of daunomycin (rubomycin) were prepared and inves...

This article defines some of the terms used in chiral chemistry and some of the basic mechanistic issues that arise in stereochemistry in pharmacology. Attention is also drawn to the impact of stereochemistry on drug regulation and its significance for new drug development. The stereoselectivity of drugs is underpinned by the fact that the human body is essentially a chiral structure. The ratio...

New liquid-crystalline materials with a perhydroazulene core were synthesized and the stereochemistry of these compounds was investigated. The mesomorphic properties of the new LC compounds were investigated by differential scanning colorimetry, polarizing optical microscopy and X-ray diffraction. We report here on the LC properties of nonchiral materials, which predominantly exhibit smectic ph...