Abstract PURPOSE To investigate the effect of radiotherapy and surgery in patients with lung cancer brain metastases (BMs) poor prognosis factors. METHODS We analyzed retrospectively 714 BMs. A 1:1 propensity score matching (PSM) was performed to balance potential confounders. Analyses overall survival (OS) risk factors for OS were assessed by log-rank test Cox proportional hazard model. RESULT...

PURPOSE To systematically review the evidence for the use of stereotactic radiosurgery or stereotactic fractionated radiation therapy in adult patients with malignant glioma. METHODS Key clinical questions to be addressed in this evidence-based review were identified. Outcomes considered were overall survival, quality of life or symptom control, brain tumor control or response and toxicity. M...

The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of radiotherapy, have enabled us to deliver higher...

Head and neck squamous cell carcinoma (HNSCC) has a reported average of around 15% metastases at presentation with chemotherapy being the mainstay of treatment for widely metastatic disease. However, in select patients with oligometastatic disease, local ablative therapy (commonly including surgery or radiotherapy) can be utilized with the possibility of improving survival, decreasing morbidity...

Abstract Background Despite current advances in systemic therapy for brain metastases, neurosurgery remains the preferred method of choice patients with limited metastases. Postoperative radiotherapy indicated to reduce risk local recurrence is recommended all after surgery. The aim this retrospective study describe clinical characteristics and survival outcomes consecutive cohorts treated by c...

Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan. Patients Methods: This retrospective single-institution analysis 249 patients, managed with whole-brain radiotherapy for brain metastases. sum scores calculated as Japanese study. following parameters were included: number metastases, vol...

Between May 2002 and August 2010, a total of 38 patients, who were clinically diagnosed as, but without surgical biopsy confirmation, intracranial germ cell tumors (GCTs) were treated at our Cancer Center. The patients were grouped into chemotherapy(n 1⁄4 21 ), radiotherapy(n 1⁄4 5), and stereotactic radiotherapy (n 1⁄4 12) based on the primary treatment. Median age of the patients at diagnosis...