نتایج جستجو برای: steroid resistant
تعداد نتایج: 235531 فیلتر نتایج به سال:
N EPHROTIC syndrome is a broad group of disorders with diverse etiologies. In common. all have proteinuria. edema. hypercholesterolemia. and hypoalbuminemia. Steroids have proven effective in some histologic groups. but many are resistant to steroids and progress to end-stage renal disease. Transplant glomerulopathy and chronic rejection also contribute heavily to renal transplant-related nephr...
INTRODUCTION Upregulation of interleukin-2 may be involved, not only in the pathophysiology of nephrotic syndrome, but also in steroid resistance treatment, by increasing expression of multidrug resistant gene-1 (MDR1) gene on lymphocytes and its product P-glycoprotein effluxing corticosteroid. Our aim was to assess the relation of serum soluble interleukin-2 receptor (sIL2R) levels and MDR1 ge...
Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including ...
The introduction of enzalutamide and abiraterone has led to improvement in the treatment of metastatic castration-resistant prostate cancer. However, acquired resistance to enzalutamide and abiraterone therapies frequently develops within a short period in many patients. In the present study, we developed enzalutamide-resistant prostate cancer cells in an effort to understand the mechanisms of ...
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