BACKGROUND Traditional non-steroidal anti-inflammatory drugs (NSAIDs) are a widely used class of therapy in the treatment of chronic pain and inflammation. The drugs are effective and can be relatively inexpensive thanks to available generic versions. Unfortunately the traditional NSAIDs are associated with gastrointestinal complications in a small proportion of patients, requiring costly co-th...

in the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in parkinsonian rats was studied using the microdialysis technique. our results showed significant differences (p<0.05) in the level of striatal glutamate between treated and non-treated damaged rats.

Background & Aim:  Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. The adverse effects they produce in the gastrointestinal tract however, often limit their utility. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. In view of this, the effect of thyme essential oil, an agent with anti-o...

Diosgenin is a steroidal saponin isolated from dioscorea opposita, which has been proven to have anti-cancer, anti-inflammatory, anti-thrombotic and immune system modulating effects in large number of pharmacological tests. also one the important raw materials for synthesis drugs, structural modification diosgenin obtain derivatives can not only improve solubility dissolution, but enhance their...

It is estimated that four million people in the United Kingdom have either osteo arthritis or rheumatoid arthritis. With the extension in lifespan seen in recent decades, the number is thought to be increasing. Many of the above will be treated with non-steroidal anti-inflammatory drugs. Lithium has been proven to be useful in the prophylaxis of affective disorders. It is also used in refractor...

CAN J ANESTH 54: 1 www.cja-jca.org January, 2007 8 Hernandez-Diaz S, Varas-Lorenzo C, Garcia Rodriguez LA. Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction. Basic Clin Pharmacol Toxicol 2006; 98: 266–74. 9 Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory dru...

Although salicylate and non-aspirin, non-steroidal anti-inflammatory drugs cause acute injury to the gastroduodenal mucosa,`~their role during long term treatment in predisposing to peptic ulcer disease and clinically important complications remains uncertain.4'" Common criticisms of existing studies include inadequate design,' investigating young volunteers rather than older patients, examinin...

Recently, the increased use of monocyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This may have potential negative effects on living organisms. The biotransformation mechanisms of monocyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals occur by hydroxylation and conjugation with glycine or glucuronic acid. Biotrans...

Although non-steroidal anti-inflammatory drugs are known to cause peptic ulcer and its complications, controversy exists about the number of deaths from ulcer which are attributable to their use. A case-control study was therefore performed to determine whether prior use of non-steroidal and other anti-inflammatory compounds was associated with an increased case fatality rate from complications...