Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the red man syndrome . Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two c...

The metahdep package provides tools to conduct a meta-analysis of effect size estimates, particularly when hierarchical dependence is present (Stevens and Taylor, 2009). The package includes convenient commands for the meta-analysis of gene expression studies. We assume the reader is familiar with meta-analysis of effect size estimates, and here adopt the framework used in Stevens and Taylor (2...

The metahdep package provides tools to conduct a meta-analysis of effect size estimates, particularly when hierarchical dependence is present (Stevens and Taylor, 2009). The package includes convenient commands for the meta-analysis of gene expression studies. We assume the reader is familiar with meta-analysis of effect size estimates, and here adopt the framework used in Stevens and Taylor (2...

Background Mycoplasma pneumoniae is widely known as the etiological agent of “atypical pneumonia”, the most common clinical aspects of the infection being bronchiolitis and acute tracheobronchitis. It can also determine extrapulmonary manifestation such as ear, nose and throat infections, neurological, cardiac or dermatological manifestations. Dermatological involvement is second most common, a...

QUESTION I recently diagnosed an erythema multiforme rash in several patients, two of whom had the major variant, Stevens-Johnson syndrome. Should these patients be managed with corticosteroids? ANSWER In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. T...