Background This study aimed to evaluate the effects of the position of an acetic acid-induced gastric ulcer and the effects of prokinetic drugs on gastric emptying. Materials and Methods Male Sprague-Dawley rats were used in this study. Acetic acid ulcers were induced either in the region between the fundus and pylorus on the anterior wall of the stomach or in the glandular region on the greate...

Sodium/hydrogen exchanger (NHE) 8 is an apically expressed membrane protein in the intestinal epithelial cells. It plays important roles in sodium absorption and bicarbonate secretion in the intestine. Although NHE8 mRNA has been detected in the stomach, the precise location and physiological role of NHE8 in the gastric glands remain unclear. In the current study, we successfully detected the e...

An 89-year-old man presented with a 1-month history of anemia. The results of a physical examination were normal. Diagnostic gastrointestinal endoscopy showed advanced atrophic gastritis, multiple ulcer scars, and a whitish, slightly depressed lesion 15mm in size in the lesser curvature of the antrum (●" Fig.1). Squamous metaplasia without atypia was diagnosed based on examination of the specim...

The first detailed description of the morphology gastric ulcer was reported ~230 years ago, but mechanism has yet to be elucidated. Moreover, peptic ulcers, including duodenal and are currently considered an infectious disease caused by Helicobacter pylori, how infection leads ulceration remains elusive. To address these challenges, a recently published Complex Causal Relationship applied analy...

Introduction An ulcer is a sore or lesion that forms in the lining of the stomach or duodenum where acid and pepsin are present. Ulcers in the stomach are called gastric or stomach ulcers. Those in the duodenum are called duodenal ulcers. In general, ulcers in the stomach and duodenum are referred to as peptic ulcers. Ulcers occur in the esophagus or in the first portion of the duodenum, the du...

The protective and therapeutic effects of Argyreia speciosa Sweet (Convolvulaceae) against ethanol-induced gastric ulcer in rats were evaluated. Ethanolic and water extracts of the aerial plant parts (200 mg/kg body weight) were orally administered daily for seven days prior to or after ulceration with one oral dose of 1 mL absolute ethanol on 24-h empty stomachs. Rats were divided into eleven ...

A WRITER, recently reviewing the known facts of the etiology of peptic ulcer, comments on the well-known observation that it is found in that part of the gastrointestinal tract that is directly exposed to gastric juice, and is subjected to the greatest mechanical stress by the passage of the gastric contents.1 Another established fact is the frequent association of ulcer with hyperchlorhydria, ...

The literature, and particularly the statistical evaluation of peptic ulcer, is vast and ordinarily there should be little excuse for adding to it, unless one has some definite reason. It is well recognized that all over the world this disease pattern in the last few decades has undergone certain changes with regard to the duodenal-gastric ulcer ratio, sex incidence, and the occurrence of compl...