The ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease domain. One of their main functions is shedding of membrane proteins. The aim of this study was to test the hypothesis that ADAM-17 (also known as tumor necrosis factor-alpha converting enzyme) is involved in breast cancer progression. Overexpression of ADAM-17 in MCF-7 breast cancer cells increased in vitr...

“malakoot” story (literally celestial kingdom), the only novel written by bahram sadeghi, is one of the memorial work that has been witten under the influence of “boof-e-koor” story (literally blind owl) written by sadegh hedayat by a distinctive style and during a specific period of time. aside from unique content of this story, form and structure of this work are also remarkable and marvelous...

abstract the present study is conducted to find various forms of times in two fictional genres “tale” and “minimalist story”, and also to disclose the factors behind the difference of the aforementioned forms in the two mentioned genres. time is represented in the levels of plot, setting, language and the images in various forms. in case of tales, due to the absence or weakness of the plot, the...

BACKGROUND Our study is to research the effect of inhibited ADAM-17 expression through the Notch pathway in renal carcinoma. METHODS Immunohistochemistry and western blot were used to examine the expression of ADAM-17 protein in renal cancer tissues. Proliferation and cell invasion of 786-o cells, as well as OS-RC-2 cells, after treatment with two different inhibitors of the Notch pathway, we...

In this study, the seismic inter-story drift of structures is estimated by a combination of mode-acceleration equations with the modelling of high-rise buildings with flexural and shear cantilever beams. In the equation presented for calculating the inter-story drift, having less knowledge of the building is adequate and this issue is of significance in estimating the nonstructural component fo...

Optimization algorithms for training deep models not only affects the convergence rate and stability of the training process, but are also highly related to the generalization performance of the models. While adaptive algorithms, such as Adam and RMSprop, have shown better optimization performance than stochastic gradient descent (SGD) in many scenarios, they often lead to worse generalization ...

There are two competing approaches sustainability in agriculture. One stresses a strict economic approach in which market forces should be allowed to guide the activities of agricultural producers. The other advocates the need to balance economic with environmental and social objectives, even to the point of reducing profitability. This paper shows how the writings of the 18 century moral philo...

The ADAMs (a disintegrin and metalloproteinase) comprise a family of multidomain transmembrane and secreted proteins. One of their best-established roles is the release of biologically important ligands, such as tumor necrosis factor-alpha, epidermal growth factor, transforming growth factor-alpha, and amphiregulin. Because these ligands have been implicated in the formation and progression of ...

The ADAMs (a disintegrin and metalloprotease) family of proteins is involved in a variety of cellular interactions, including cell adhesion and ecto- domain shedding. Here we show that ADAM 12 binds to cell surface syndecans. Three forms of recombinant ADAM 12 were used in these experiments: the cys-teine-rich domain made in Escherichia coli (rADAM 12-cys), the disintegrin-like and cysteine-ric...