Approximately 20% of caustic ingestions result in some degree of esophageal injury. Alkaline materials are the most frequent corrosive materials ingested.     The physical form and PH of ingested materials play a critical role in the site and type of gastrointestinal injury (PH > 12 or PH < 1.5, crystalline drain cleaners). Unlike Alkaline solutions, strong acids are bitter, burn on contact and...

Gastric cancer (GC) is one of the most important diseases that affected health in all over the world (Zare et al., 2013; Lin et al., 2014). Gastric cancer is the most general deadly cancer with approximately 738,000 deaths per year that over 70% of them occur in the developing countries (Jemal et al., 2011). Northern and northwestern regions of Iran are high risk areas for gastric cancer (Falla...

Hydrogen sulphide (H₂S) is produced endogenously via two enzymes dependent on pyridoxal phosphate (PLP): cystathionine beta-synthase (CBS, EC 4.2.1.22), cystathionase γ-liase (CTH, EC 4.4.1.1), and a third, 3-mercaptopyruvate sulfurtransferase (MPST, EC 2.8.1.2). H₂S strengthens the defence mechanisms of the gastric mucosal barrier, and plays an important role in gastroprotection, including the...

background: a reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ-isms to kill the parasite. however, it is not well known whether these intermediates cause dna damage and oxidative stress in goats infected with babesia ovis . the pur-pose of this study was to clarify the effects of babesiosis on basal leve...

conclusions in sum, the results indicate that the consumption of vitamin c can decrease the lipid peroxidation and increase the level of tac, and is ineffective on enzyme and non-enzyme antioxidants and muscle damage. objectives the aim of the present research was to study the effect of endurance swimming training with the consumption of a vitamin c supplement on indices of oxidative stress and...

background: cadmium (cd) is a heavy metal which is widely spread in our surroundings and has a very strong ability to accumulate in the body organs such as spleen. in this study we aimed to determine the genotoxicity and cytotoxicity effects on mice spleen  treated with cadmium. methods: thirty male mice were enrolled in this study and kept in standard conditions. mice were randomly divided int...

background: occupational exposure to excessive level of copper results in many adverse health effects. objective: to measure pulmonary function, oxidative stress, and extent of dna damage in workers of a copper processing industry. methods: 30 men working in a copper processing industry and 30 men matched for age and socioeconomic status (comparison group) were included in this study. pulmonary...

BACKGROUND Sulphydryl compounds and nitric oxide are essential in maintaining gastric mucosal integrity. AIMS To characterise the gastric damage induced by a sulphydryl blocker, to evaluate the role of nitric oxide in its pathogenesis, and to reveal its possible prevention by scavenging of free radicals. METHODS Gastritis was induced in rats by addition of iodoacetamide (0.1%) to the drinki...

Abstract Background Sepia officinalis ink is a bioactive secondary metabolite rich in melanin granules, which has wide range of nutritional and therapeutic values also been used to prevent various gastrointestinal disorders. Gastric ulcer, the most common disease, characterized by severe gastric mucosa damage, its prevention currently one main goals clinical experimental studies. Thus, present ...

BACKGROUND Helicobacter pylori is an independent risk factor for gastric cancer, and this association may be due to the bacterium causing reactive oxygen species mediated damage to DNA in the gastric epithelium. High dietary ascorbic acid intake may protect against gastric cancer by scavenging reactive oxygen species. AIMS To assess reactive oxygen species activity and damage in gastric mucos...