The T cell receptor (TCR) alphabeta heterodimer communicates ligand binding to the cell interior via noncovalently associated CD3gammaepsilon, CD3deltaepsilon, and zetazeta dimers. While structures of extracellular components of the TCR-CD3 complex are known, the transmembrane (TM) domains that mediate assembly have eluded structural characterization. Incorporation of the zetazeta signaling mod...

We report the structural effect of 2'-deoxy-2',2'-difluorocytidine (dFdC) insertions in DNA strand a : RNA hybrid duplex and self-complementary duplex. In both cases, modification slightly destabilizes provokes minor local distortions that are more pronounced case hybrid. Analysis solution structures determined by NMR methods show dFdC is an adaptable derivative adopts North type sugar conforma...

Abstract Sr-substitution in the crystal structure of bredigite has been studied detail. Samples a hypothetical solid-solution series with nominal composition Ca 7-x Sr x Mg[SiO 4 ] (x = 0, 2, …,7) have prepared from sinter reactions temperature range between 1275 and 1325 °C characterized using powder single-crystal X-ray diffraction. Synthesis runs 1 resulted compounds increasing contents, for...

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. EAV particles contain seven structural proteins: the nucleocapsid protein N, the unglycosylated envelope proteins M and E, and the N-glycosylated membrane proteins GP(2b) (previously named G(S)), GP(3), GP(4), and GP(5) (previously named G(L)). Proteins N, M,...

To compare endogenous cholesterol biosynthesis measured by deuterium incorporation (DI) and mass isotopomer distribution analysis (MIDA), cholesterol fractional and absolute synthetic rates were measured simultaneously by both techniques under identical physiological conditions. Twelve subjects (22 to 39 years of age) underwent a dual stable isotope protocol, involving oral deuterium oxide admi...

Averaged across crop, year and season , residue cover reduction was significantly less for coulter-type applicators than for disk-type applica-tors (P<0.001), disk-type applicators reduced residue cover significantly less than chisel and sweep injectors (P<0.001), and chisel and sweep injec-tors reduced residue cover similar to a tandem disk (P=0.398). Ranges of values to estimate the percentag...

Patients with cirrhosis of the liver can develop gastric or gastroesophageal varices, which can bleed and become life threatening Gastric varices pose unique management challenges, as endoscopic therapies are limited Balloon-occluded retrograde transvenous obliteration (BRTO) is a treatment option for gastric varice at high risk of bleeding The BRTO is recommended for patients with gastrorenal ...