this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

The article deals with the problem of using various installations for mixing and preparing liquid feed mixtures in animal husbandry. analysis domestic foreign capable performing this function is carried out. But during review process, many shortcomings problems were identified that needed to be solved by developing a new design would eliminate all problems. Therefore, two horizontal vertical ve...

following the idea of $l$-fuzzy neighborhood system as introduced byfu-gui shi, and its generalization to $(l,m)$-fuzzy neighborhood system, the relationship between  $(l,m)$-fuzzy topology and $(l,m)$-fuzzy neighborhood system will be further studied. as an application of the obtained results, we will describe the initial structures of $(l,m)$-fuzzy neighborhood subspaces and $(l,m)$-fuzzy top...

Harrah’s Cherokee Casino and Hotel is an extreme and unusual example of revenue management techniques. Typical revenue management installations yield revenue enhancements of 3-7%. Harrah’s, chainwide, has seen 15% improvements, with Harrah’s Cherokee Casino and Hotel perhaps the most excessive beneficiary, despite serving no alcohol and having no traditional table games. Further, many tradition...

A number of semi-permanent light art installations and sculptures was commissioned from different artists, each highlighting a different historical building or one of the many canal-bridges in the city. The installations will all remain in place for a minimum of 10 years. The light art installations together constitute a walking route through the city center under the name “Trajectum Lumen”. Th...

We address the issue of enabling text entry for walk-up-and-use interactive tabletop displays located in public spaces. Public tabletop installations are characterized by a diverse target user group, multiperson interaction, and the need for high approachability and intuitiveness. We first define the design constraints of text-entry methods for public tabletop installations such as clear afford...

This is an overview of the three installations Hoppsa Universum, CLOSE and Flying Carpet. They were all designed as choreographed sound and music installations controlled by the visitors movements. The perspective is from an artistic goal/vision intention in combination with the technical challenges and possibilities. All three installations were realized with video cameras in the ceiling regis...

This paper presents a solution for automating dual boot Linux and Windows NT 4.0 installations on a PC. The process is automated to the extent that one starts with a PC with a blank hard disk and ends up with a fully customized dual-boot PC. The process involves booting a PC with a floppy disk; choosing what kin of system is required from a menu and then, once the install begins, popping out th...

This paper conducted an economic analysis of the viability of five solar photovoltaic installations in County Tipperary, Ireland. Economic barriers along with policy recommendations are also discussed in detail in order to incentivise solar photovoltaics installations in Ireland. Using costings, solar photovoltaic energy output data and solar radiation data it is also investigated how Irish fin...

the efficacy of genre-based approach to teaching writing has been regarded as an influential practice in l2 writing pedagogy (hyland, 2007). however, there is still gap between actual structures found in reading materials recommended as textbooks and discourse patterns recommended for l2 writing in efl contexts, the gap which would highlight the problems of genre and rhetorical patterns for tea...