BACKGROUND Buprenorphine is used in the treatment of opioid dependence. Due to its pharmacology, the transfer from methadone to buprenorphine may precipitate withdrawal symptoms. METHODS Methadone maintained patients with clinical indicators of stability who were seeking withdrawal from methadone were recruited from three Australian states. Patients on methadone doses between 30 and 40 mg wer...

buprenorphine is a partial mu agonist and kappa antagonist which is used for the treatment of pain and opioid addiction. a mixture of buprenorphine hydrochloride and naloxone hydrochloride has been approved for the treatment of opioid dependence.in this study a third order derivative spectrophotometric method based on zero-crossing technique has been used for the simultaneous determination of b...

Buprenorphine has been widely recommended for treatment of pain in rodents. We have previously documented that the recommended postoperative oral dose of buprenorphine in male Long-Evans rats, 0.5 mg/kg, is not as effective as the recommended parenteral dose of buprenorphine (0.05 mg/kg, s.c.) as an analgesic. In the series of experiments reported here, we compared: the analgesic effect of bupr...

Buprenorphine is an opioid that has a complex and unique pharmacology which provides some advantages over other potent mu agonists. We review 12 reasons for considering buprenorphine as a frontline analgesic for moderate to severe pain: (1) Buprenorphine is effective in cancer pain; (2) buprenorphine is effective in treating neuropathic pain; (3) buprenorphine treats a broader array of pain phe...

conclusions buprenorphine is more suitable for treating opiate addiction in males since it does not affect normal testicular structure and function. results stereological analysis of rat testes showed no significant effect of methadone and buprenorphine administration on the testis volume (p > 0.05). however, microscopic stud­ies of rat tissues in the methadone-administered group showed atrophi...

Clinical Questions: 1. If a female patient of child-bearing age is requesting buprenorphine treatment, what should I do? (i.e. informed consent, birth control, etc) 2. If a patient is already on buprenorphine. Should I keep her on it during a pregnancy? 3. Does it matter whether she is given the mono (buprenorphine) or combo (buprenorphine/naloxone) product? 4. If a new opioid-dependent patient...

AIMS To examine concurrent buprenorphine and benzodiazepine consumption and to compare opioid toxicity symptoms induced by methadone and buprenorphine, examining factors associated with the reporting of these symptoms. DESIGN Self-report cross-sectional survey. SETTING Five needle syringe programmes and five opioid substitution treatment services in Melbourne, Australia. PARTICIPANTS A to...

Buprenorphine safety in overdose has been debated recently, but no mortality data related to this compound from the UK have been published. To gather together all of the buprenorphine mortality figures, a number of different sources have been checked. To inform on buprenorphine safety issues, accessible information related to its availability indicators (i.e. prescriptions; seizures) data for t...

Abstract Background: This study compared the success rates of buprenorphine and clonidine in detoxification of heroin-dependents and evaluated the recurrence of drug abuse in patients taking naltrexone in a 6 month follow up. Methods: A double-blind study was carried out in Kerman’s psychiatric hospital on heroin-dependents seeking detoxification during the years 2007-2009.These patient...

Objectives: This study presents the comparative safety and side effect profiles of buprenorphine and methadone, including gender relationships, from a clinical trial comparing buprenorphine and methadone in the outpatient treatment of opioid dependence. Methods: One hundred sixty-four opioid dependent volunteers age 18–50 years were randomized to buprenorphine (n = 84) or to methadone (n = 80) ...