Forty-one patients suffering from grass pollen allergy underwent specific immunotherapy with standardized allergen extract consisting of six grass pollens (H-Al per os) administered either sublingually or supralingually for one year. In order to investigate clinical and immunological changes induced by the administration of allergens via the oral mucosa, the double-blind, placebo-controlled, ra...

Allergic rhinitis, allergic conjunctivitis, and allergic asthma have been steadily increasing in prevalence in recent years. These allergic diseases have a major impact on quality of life and are a major economic burden in the US. Although allergen avoidance and pharmacotherapy are currently the mainstays of therapy, they are not always successful in treating patients' symptoms effectively. If ...

Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal al...

The main objective of this study is to analyze the effects sublingual specific immunotherapy and conventional drug therapy on inflammatory factors immune function in children with allergic rhinitis. research subjects were divided into three groups, group A received administration dust mite drops, B routine treatment such as passive intervention topical hormones, antihistamines nasal irrigation ...

Background Sublingual immunotherapy (SLIT) has been regarded as a viable alternative to subcutaneous immunotherapy (SCIT) since its introduction in 1986. Several studies have demonstrated the efficacy of SLIT. The safety profile of SLIT is superior to that of SCIT. No fatalities have been reported, and severe systemic reactions are rare. The rate of adverse event (AE) after SLIT is variable in ...

Background Allergen specific immunotherapy is an effective treatment of allergic rhinitis. It is most commonly administered as repeated subcutaneous injections or as a daily sublingual tablet during 3-5 years. In order to shorten the treatment duration previous studies have evaluated the use of intralymphatic injections (ILIT) with promising results. This study assesses safety and efficacy of I...

Immunotherapy – 2072. Therapeutic effect and higher safety profile for allergic asthma in Cuban patients with sublingual immunmotherapy using tropical domestic mite allergen vaccines Raúl Lázaro Castro Almarales, Mirta Alvarez Castello, Mercedes Ronquillo Díaz, Mayda Gonz&#225lez León, Alexis Labrada Rosado, José S Rodr&#237guez Canosa, Bárbara Ivonne Navarro Viltres, Yunia Olivia Diaz, Maytee ...

Background To assess the cumulative and allergen-specific magnitude of effect, and its relative clinical impact, of sublingual allergy immunotherapy with carbamylated monomeric allergoids for allergic rhinoconjunctivitis. Carbamylated allergoids are hypoallergenic extracts with enhanced bioavailability, consequent to a partial resistance to enzymatic degradation, providing efficient dose-tuning.

BACKGROUND To date, no predictive tests for the clinical response to allergen-specific immunotherapy (ASI) are available. Therefore an in vivo or in vitro test would be of great value. OBJECTIVE We sought to evaluate pretreatment parameters used in diagnosing allergic rhinitis and determining serum specific IgE (s-IgE) levels, serum total IgE (t-IgE) levels, and blood eosinophil counts and to...

Sublingual immunotherapy (SLIT) for allergic respiratory diseases was first described in 1986 and immediately appeared as a viable alternative to the traditional subcutaneous route. Since then, more than 60 randomized controlled trials have been published, almost all with very favorable results. The average improvement over placebo in symptom score and medication use was always greater than 20%...