There is a simultaneous increase of both trypsinlike proteolytic activity and the number of granules in the convoluted granular tubules (CGT) of the rat submandibular gland (SMG) during postnatal development.1 Development and maintenance of the CGT granules and proteolytic activity are partially dependent on sex hormones, pituitary secretions, and thyroxine.14 Recently, five trypsinlike enzymes...

Calorie restriction reduces mammary mitogenesis and tumorigenesis. To test whether epidermal growth factor (EOF) levels are influenced by calorie intake, 72 four-week-old C3H/HeOu mice were separated into two groups and either fed ad libitum (group AL) or calorie-restricted at a mean 19% (group CR). Three mice from each group were evaluated when 6, 8,10, and 12 weeks old for submandibular gland...

Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of...

Before this study, there had been no research evaluating the relationship between a lysosomal exoglycosidase profile and secretory function in the salivary glands of rats with streptozotocin- (STZ-) induced type 1 diabetes. In our work, rats were divided into 4 groups of 8 animals each: control groups (C2, C4) and diabetic groups (STZ2, STZ4). The secretory function of salivary glands-nonstimul...

The binding of [l ,2-3H]dihydrotestosterone by cytoplasmic extracts of submandibular glands from normal male mice and from mice carrying the X-linked gene for testicular feminization (Tfm/Y) has been studied by density gradient centrifugation and gel filtration. Androgen binding in this tissue was found exclusively in the portion of the gland that is known to contain androgen-dependent elements...

TPX2 is a microtubule-associated protein and is required for microtubule formation at kinetochores in mammalian cells. The purpose of this study was to clarify the expression of TPX2 mRNA and correlation between TPX2 and clinicopathological factors in salivary gland carcinomas. The expression of TPX2 mRNA was investigated in 20 human salivary gland carcinomas (8 mucoepidermoid carcinomas, 7 ade...

Submandibular acinar glands secrete numerous proteins such as digestive enzymes and defense proteins on the basis of the exocrine secretion mode. Exocytosis is a complex process, including a soluble NSF attachment protein receptor (SNARE)-mediated membrane fusion of vesicles and target membrane and the additional activation of cytoskeletal proteins. Relevant data are available predominantly for...

Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (klotho-/-, 4 weeks old). Microarray analysis showed that 195 genes were differentia...