Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus. They were moderately inhibitory to vaccinia virus but not inhibitory to adenovirus, coxsackievirus, poliovirus, parainfluenza virus, and re...

The rate of hyaluronic acid and sulfated mucopolysaccharide production was measured for hamster embryo fibroblasts and for general oncogenic lines derived by virus transformation. A striking increase in both the rate of hyaluronic acid synthesis and the amount of cell-associated polymer was observed after transformation by herpes simplex type-2 or SV40 virus. Although no corresponding change wa...

The chemoenzymatic synthesis of heparan sulfate tetrasaccharide (1) and hexasaccharide (2) with a fluorous tag attached at the reducing end is reported. The fluorous tert-butyl dicarbonate ((F)Boc) tag did not interfere with enzymatic recognition for both elongation and specific sulfation, and flash purification was performed by standard fluorous solid-phase extraction (FSPE). Based on an (F)Bo...

The intracellular transport of sulfated glycosaminoglycans (heparan sulfate and chondroitin sulfate) and glycoproteins of the prolactin (PRL) granule matrix, as well as that of PRL, was studied using a system of double-labeled bovine anterior pituitary slices. [(35)S]sulfate was used to label sulfated macromolecules and L-[(3)H]leucine to label PRL. In membraneless granules (isolated from a PRL...

At CITO Clinic of bone pathology new biocomposite material Osteomatrix was used in 15 patients (mainly with tumors and tumor-like diseases) for the plasty post-resection defects. is composed collagen, hydroxyapatite sulfated glycosaminoglycanes. produced at together Conectbiopharm Ltd. form granules blocks. Observation dynamics roentgenologic control showed good tolerance by distinct accelerate...

Correction for ‘Hybridized sulfated-carboxymethyl cellulose/MWNT nanocomposite as highly selective electrochemical probe trace detection of arsenic in real environmental samples’ by Youssef O. Al-Ghamdi et al. , RSC Adv. 2023, 13 18382–18395, https://doi.org/10.1039/D3RA03808D.

The adsorption and photocatalytic degradation of trimethyl phosphate (TMP) triethyl (TEP), two environmentally relevant model pollutants, have been studied on commercial anatase TiO2 sulfate-terminated nanoparticles by means operando diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy 2D correlation (2D COS). It is concluded that both TMP TEP adsorb dissociatively TiO2, while th...

Sulfated tyrosines at the amino terminus of the principal HIV-1 coreceptor CCR5 play a critical role in its ability to bind the HIV-1 envelope glycoprotein gp120 and mediate HIV-1 infection. Here, we show that a number of human antibodies directed against gp120 are tyrosine sulfated at their antigen binding sites. Like that of CCR5, antibody association with gp120 is dependent on sulfate moieti...

Colloidal gold particles with functionalized organic shells were applied as novel selectin binders. The ligand shell was terminated with different monocyclic carbohydrate mimetics as simplified analogs of the sLe(x) unit found in biological selectin ligands. The multivalent presentation of the sulfated selectin binding epitopes on the gold particles led to extremely high binding affinities towa...

Heparin-induced thrombocytopenia (HIT) is an important complication of heparin therapy. Although there is general agreement that platelet activation in vitro by the HIT IgG is mediated by the platelet Fc receptor, the interaction among the antibody, heparin, and platelet membrane components is uncertain and debated. In this report, we describe studies designed t o address these interactions. We...