introduction: traumatic injuries to the teeth are among the most serious dental accidents, with the anterior teeth being mostly affected. some consequences of dental trauma include misshaping, speech defects, psychological and social effects. the knowledge of the field can reduce the suffering, cost, and the time for patients, parents, and health care providers. the aim of this study was to inv...

Colorado Denver. The inducible head-and-neck specific knockout system consists of two mouse lines, the K14.CrePR1 or K5.Cre*PR1 mice, in which Cre recombinase can be activated in head-and-neck epithelia by RU486 (1, 2), and the Smad4f/f mice, in which the Smad4 gene is floxed (3). These mouse lines were crossbred to generate compound mice, allowing for homozygous Smad4 deletion (Figure S1A). Li...

OBJECTIVE To characterize the types of comparators and endpoints used in efficacy trials for approvals of supplemental indications, compared with the data supporting these drugs' originally approved indications. DESIGN Systematic review. SETTING Publicly accessible data on supplemental indications approved by the US Food and Drug Administration from 2005 to 2014. MAIN OUTCOME MEASURES Typ...

Supplementary Materials and Methods A total of 236 psoriasis cases of all Chinese Han origin, including 62 with GPP, 174 with PsV and 365 controls, were recruited in our study ( Table 1s). Individuals in the PsV group had at least two psoriatic scales or a single scale occupying at least 1% of the total body surface outside the scalp, and all had a history of psoriasis at least 10 years. All pa...

The International Headache Genetics Consortium (IHGC) study collected 23 285 cases with migraine and 95 425 controls from 29 studies for a meta-analysis of genome-wide association data. For a subset of the cohorts sufficiently detailed phenotype information was available to allow subclassification into either of the two migraine subtypes, migraine with aura (5 118 cases versus 74 239 controls) ...

cDNA Cloning and Structure of the Mouse Rictor Gene A 867 bp rictor cDNA fragment was originally obtained as mouse homologue of the pianissimo gene of Dictyostelium (Chen et al., 1997) during a search for genes that were preferentially expressed in the insulinoma-derived cells. Using this cDNA fragment as a probe, additional rictor cDNA fragments were isolated from a pituitary corticotroph AtT2...

background & aim: regional odonto dysplasia (rod) is an unusual nonhereditary of teeth with significantly clinical and radiographic features. affected teeth usually remain unerupted or semi-erupted with a discolaration and irregular shape. radiographically these teeth have a large pulp chamber and thin layer of enamel and dentin with similar density. this article is introducing a female patient...