previous studies have reported the efficacy of baclofen in the treatment of gastroesophageal reflux diseases (gerd). the objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained release baclofen (sr baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of gerd. a prospective, double blind, place...

Trimetazidine dihydrochloride, a cellular antiischemic agent indicated in the management and prophylaxis of angina pectoris is given as 20 mg thrice daily in the conventional dosage regimen. The purpose of the present study was to formulate and evaluate twice a day extended release tablets containing 30 mg trimetazidine dihydrochloride. The method developed to formulate these extended release t...

the present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of ph dependent system (to prevent the premature release of drug in the upper git) and enzymatically degradation system (to ensure the specificity of drug release in the colon). the drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...

Tramadol is a veterinary analgesic for dogs. In this study, the steady-state pharmacokinetics of sustained-release (SR) tablet (Tramagetic OD®) and immediate-release capsules (IR) were compared. crossover design, six dogs received five doses IR 50 mg four times day (qid), or two SR 200 once (sid). Eight blood samples collected per dog, formulation, up to 6 24 h after last dose, respectively. Se...

In the present study sustained release matrix tablets of Theophylline were prepared by direct compression method using different grades and ratios of hydroxy propyl methyl cellulose in presence of ethyl cellulose to examine their influence on tablet properties and drug release profile. Theophylline is used to treat chronic obstructive pulmonary disease (COPD) and asthma. The drug has a narrow t...

Bilayered tablet is an important pharmaceutical technology for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, to separate incompatible substances and also formulating sustained release tablet in which one layer is immediat...

High-amylose corn starch, that contains 70% of amylose chains and 30% of amylopectin, has been used to obtain substituted amylose (SA) polymers. Tablets have been prepared by direct compression, i.e. dry mixing of drug and SA, followed by compression, which is the easiest way to manufacture an oral dosage form. Until now, their controlled-release properties have been assessed only by an in vitr...

The thermal stability of polyethylene oxide (PEO) in sustained release tablets prepared by hot-melt extrusion was investigated. The weight average molecular weight of the polymer was studied using gel permeation chromatography. The chemical stability of PEO was found to be dependent on both the storage and processing temperature, and the molecular weight of the polymer. Storage of the polymer a...