Resveratrol is a natural polyphenol present in the Japanese knotweed. It exhibits variety of chemopreventive and anti-proliferative effects against different cancer cell lines. During skin carcinogenesis, radical scavenging activity gets altered which are important to prevent deleterious effect free radicals. The study targeted elucidate anti-cancer potential resveratrol 7, 12-dimethylbenz[a]an...

Background: The radioprotective effect of Grewia asiatica fruit (GAE) which contains anthocyanin type cyanidin 3- glucoside, vitamin C, A, minerals, carotenes and dietary fibers etc was studied. Materials and Methods: For study Swiss albino mice were divided into five groups-1. Control (vehicle treated) 2. GAE treated (700 mg / Kg. b.wt / day for fifteen days), 3. Irradiated (5 Gy), 4. G...

Background: From the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. Radiation protection concepts and philosophy have been evolving over the past several decades. Materials and Methods: The radioprotective of effect of Aloe vera leaf extract (1000 mg /kg b.wt. orally for 15 consecutive days) has been studied against 6 Gy of gamma radiation in ...

    Background & Objective:  Acetaminophen is known as the most common agent which causes hepatic and renal toxicity in human and experimental animals at supra-therapeutic doses. The current study investigated the protective effects of Descurainia sophia seed extract on the acetaminophen-induced nephrotoxicity markers in male mice.  Materials & Methods:  Experimental male mice (n=60, Swiss alb...

Abstract: Background: Bacterial meningitis is a serious medical disorder that should be treated as soon possible. Aim: The effect of ansamycin nanoformulation on Escherichia coli induced was investigated. Materials and Methods: By injecting directly into the brains Swiss Albino mice, an experimental model established. Results: As expected, TNF-α, IL-6, IL-10 secretion stimulated, following neut...

Mouse 3T3-Swiss albino cells are widely used as feeder cells to culture the human epidermis for the treatment of burns. To minimize the risk of xenoinfection, quality control of the feeder cells is required in the Japanese guidelines on regenerative medicine using feeder cells. We characterized three lots of 3T3-Swiss albino cells that are publicly or commercially available in Japan. One lot, w...

The cytokines IFN-?, interleukin IL-1?, and TNF-? each up regulate the expression of major histocompatibility complex (MHC) are therefore considered as inflammatory markers. present study aimed to measure serum levels in mice after induction diabetes with streptozotocin correlate their lipid glycaemic profiles. included 40 Swiss Albino (20 males 20 females), half male female groups were made di...