PURPOSE Two coding single nucleotide polymorphisms (SNPs) in lysyl oxidase-like 1 (LOXL1) are major genetic risk factors for pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG) in diverse populations. However, recent conflicting results suggest that the currently known disease-associated missense variants R141L and G153D are not causal and that they may be proxies for other un...

Sir, Recently, a new carbapenemase, NDM-1, encoded by blaNDM-1, has become a global concern. Previous work reported the prevalence of blaNDM-1 mainly in animal-associated and human-associated bacteria (e.g. patients and animals – ). Walsh et al. detected blaNDM-1 in seepage samples and drinking water, indicating the dissemination of blaNDM-1 in the environment. Soil, one of the largest natural ...

In 1980, polymorphic variance in the human genomewasused to generate a first, physical map allowing monogenic traits to be traced to certain chromosomal regions. Due to the recognition of fragment length polymorphisms (microsatellite markers) with several different alleles at the same chromosomal locus, single nucleotide polymorphisms (SNP) became neglected in this instance for a long time. The...

background: most of the amino acids are encoded by more than one codon, termed as synonymous codons. synonymous codon usage is not random as it is unique to species. in each amino acid family, some synonymous codons are preferred and this is referred to as synonymous codon usage bias (scub). trends associated with evolution of scub and factors influencing its diversification in plastomes of gen...

Identification of functionally relevant potential genomic loci using an economical, simpler and user-friendly genomics-assisted breeding strategy is vital for rapid genetic dissection of complex flowering time quantitative trait in chickpea. A high-throughput multiple QTL-seq strategy was employed in two inter (Cicer arietinum desi accession ICC 4958 × C reticulatum wild accession ICC 17160)- a...

Abstract: This study was carried out to investigate the effects of selection on single nucleotide polymorphisms (SNPs) in coding sequence leptin receptor (LEPR) gene and possible associations between SNPs’ some meat yield traits Japanese quail lines. Fifteen generations divergently selected two lines (HBW LBW) for 5-weeks age body weight a control were used as materials this study. A 348-bp par...

Heat shock proteins (HSPs) associated with stress reactions play an important role in cell survival by activating numerous regulatory and inducing black apoptosis. This study aimed to identify the potential SNPs of HSP70 gene Kacang goats Indonesia. Forty-three were selected from Sidoarjo Tulungagung districts. The DNA isolated blood samples was successfully amplified using polymerase chain rea...