نتایج جستجو برای: synthetic peptides
تعداد نتایج: 213529 فیلتر نتایج به سال:
Proteins and peptides are attractive chemical building blocks to encapsulate protect active substances thanks their biocompatibility, biodegradability, low immunogenicity, added functionality compared synthetic polymers. This review provides a comprehensive overview of micro- nanocapsules predominantly made proteins—both natural artificially produced—and peptides, detailing different fabricatio...
Advances have been made in the development of vaccines based on synthetic peptides and polypeptides representing tumor-associated antigens and protective epitopes of viruses and parasites. Advances within the past year include the design of vaccines based on artificial proteins, for example multiantigen peptides, branched polypeptides, fusion and recombinant peptides, as well as single T cell e...
ELISA and RIFI are currently used for serodiagnosis of canine visceral leishmaniasis (CVL). The accuracy of these tests is controversial in endemic areas where canine infections by Trypanosoma cruzi may occur. We evaluated the usefulness of synthetic peptides that were selected through phage display technique in the serodiagnosis of CVL. Peptides were chosen based on their ability to bind to Ig...
The mechanisms by which pulmonary surfactant protein B (SP-B) affects the surface activity of surfactant lipids are unclear. We have studied the peptide/lipid interactions of the amino-terminal amphipathic domain of SP-B by comparing the secondary conformations and surface activities of a family of synthetic peptides based on the native human SP-B sequence, modified by site-specific amino acid ...
Food spoilage is caused by the undesirable growth of microorganisms in food products. This can lead to global loss and waste food. It estimated that 1.3 billion tons edible produced for human consumption either lost or wasted each year. Different preservation techniques have been developed prevent this spoilage; however, problem still occurs. Plants ability produce compounds protect themselves ...
Multicellular organisms are constantly exposed to a multitude of pathogenic microbes. Infection is inhibited in vivo by the innate and adaptive immune system. Mycobacterium species have emerged that are resistant to most antibiotics. We identified several naturally occurring cationic antimicrobial peptides that were active at low micromolar concentrations against Mycobacterium smegmatis. Human-...
Quantitating the frequency of T cell cross-reactivity to unrelated peptides is essential to understanding T cell responses in infectious and autoimmune diseases. Here we used 15 mouse or human CD8+ T cell clones (11 antiviral, 4 anti-self) in conjunction with a large library of defined synthetic peptides to examine nearly 30,000 TCR-peptide MHC class I interactions for cross-reactions. We ident...
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