Objective(s):Degradation of sphingosine 1-phosphate (S1P), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. Since the tumor progression effects of S1P and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of S1P in tumor p...

objective: today, esophageal cancer (ec) has become one of the most common cancer types in china. therefore, new drug and therapeutic strategies are urgently needed to improve postoperative survival rate of patients with ec. as a food additive, several lines of evidence have shown that citric acid can be served as glycolysis suppressor to inhibit growth of some tumor cells. however, little is k...

background: radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. however, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. in recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. the aim of the current study was to e...

background: numerous molecules in papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. objective: numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few...

olea europaea l. commonly known as olive has been traditionally used for the prevention and treatment of many diseases since ancient times. olive has been reported to possess a broad spectrum of pharmacological properties. in the present study we investigated the activity of aqueous extract of olea europaea l. fruit at various concentrations on a2780, a172 and hfff2 cell lines proliferation by ...

Objective(s):In previous investigations, we have shown para-nonylphenol (p-NP) caused significant reduction of proliferation and differentiation of rat bone marrow mesenchymal stem cells (MSCs) in vitro. In this study, we first treat the rats with p-NP, then carried out the biochemical and morphological studies on MSCs. Materials and Methods: Proliferation property of cells was evaluated with t...

The expression of microRNA 198 which is localized in human chromosome 13q13.3 downregulated many malignant tumors. purpose this study to investigate the regulatory effects on non-small cell lung cancer and associated mechanism. levels lines tumor tissues were determined using reverse transcription polymerase chain reaction method. Overexpression adenocarcinomic alveolar basal epithelial cells, ...

Objective: Anticancer activities of Schiff bases S1 and S2 against MG-63 human osteosarcoma cells were performed described using an in vitro evaluation employing cytotoxicity apoptosis assay. Methods: used MTT assay to examine the effect compound on cell viability (S1 S2). Cell morphologies IC50 values obtained. The acridine orange (AO)/ethidium bromide (EB) dual staining technique was determin...

Introduction: Vinca rosea, an important medicinal plant, is well-known for its anticancer properties especially against breast cancer. In this study, we compared the cytotoxic effects of methanolic extracts of the vegetative (young and old leaves) and reproductive (flowers) organs of this plant on a human squamous cell carcinoma using MTT assay. Methods: The cytotoxic effects of Vinca rosea'...

This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion, and that TGF-beta production by T lymphocytes is important in T cell interactions with other cell types. TGF-beta was shown to inhibit IL-2-depen...