The striking and unique structural feature of the T cell receptor (TCR) beta chain is the bulky solvent-exposed FG loop on the Cbeta domain, the size of almost half an immunoglobulin domain. The location and size of this loop suggested immediately that it could be a crucial structural link between the invariant CD3 subunits and antigen-recognizing alpha/beta chains during TCR signaling. However...

In single-index models the link or response function is not considered as fixed. The data determine the form of the unknown link function. In order to obtain a flexible form of the link function we specify the link function as an expansion in basis function and propose to estimate parameters as well as the link function by weak learners within a boosting framework. It is shown that the method i...