The problem of pairing in anisotropic electron systems possessing patches of fermion condensate in the vicinity of the van Hove points is analyzed. Attention is directed to opportunities for the occurrence of non-BCS pairing correlations between the states belonging to the fermion condensate. It is shown that the physical emergence of such pairing correlations would drastically alter the behavi...

An important mammalian defence strategy against intracellular pathogens is the presentation of cytoplasmically derived short peptides by major histocompatibility complex (MHC) class I molecules to cytotoxic T lymphocytes. MHC class I molecules assemble in the endoplasmic reticulum (ER) with chaperones, including calnexin and calreticulin, before binding to the transporter associated with antige...

Cancer-associated protein tyrosine kinase (PTK) mutations usually are gain-of-function (GOF) mutations that drive tumor growth and metastasis. We have found 50 JAK1 truncating mutations in 36 of 635 gynecologic tumors in the Total Cancer Care® (TCC®) tumor bank. Among cancer cell lines containing JAK1 truncating mutations in the Cancer Cell Line Encyclopedia databank, 68% are gynecologic cancer...

Strains of inuenza A virus are known to infect speciŽc subpopulations of neurons in the mouse brain. Here we report that all segments of the genome of the neurotropic inuenza A virus, strain WSN/33, can persist in the brains of immunodefective transporter associated with Antigen Processing 1 (TAP1) mutant mice. Ten to 17 months after injection of virus into the olfactory bulbs, viral RNA enco...