objective: druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. to understand such micro-environment, we performed in silico interaction analysis between a human target protein, dipeptidyl...

background: mean platelet volume (mpv) correlates with platelet activity. the relation between mpv and long-term outcome in patients undergoing percutaneous coronary intervention (pci) has been investigated in several studies. the aim of the present study was to investigate the utility of mpv in prognosticating the long-term outcome after elective pci. methods: the study cohort included 2627 pa...

Recognizing that value involves experiencing pleasure or pain is critical to understanding the psychology of value. But hedonic experience is not enough. I propose that it is also necessary to recognize that strength of engagement can contribute to experienced value through its contribution to the experience of motivational force--an experience of the intensity of the force of attraction to or ...

although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. rather, they are considered as non-coding rnas. micrornas (mirnas) are very short non-coding rnas approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and ...

introduction: recently, magnetic resonance spectroscopic imaging (mrsi), as a functional imaging method, has been used for clinical target volume definition. in this study, we used this method to define the target volume in prostate radiotherapy. material and method: in this study, we used images of 20 prostate cancer cases. mrsi and mri images were fused with ct images. then, treatment plannin...

High resolution range profile (HRRP) plays an important role in wideband radar automatic target recognition (ATR). In order to alleviate the sensitivity to clutter and target aspect, employing a sequence of HRRP is a promising approach to enhance the ATR performance. In this paper, a novel HRRP sequence-matching method based on singular value decomposition (SVD) is proposed. First, the HRRP seq...

Lower bounds on Bayes factors in favor of the null hypothesis in multinomial tests of point null hypotheses are developed. These are then applied to derive lower bounds on Bayes factors in both exact and asymptotic chi-squared testing situations. The general conclusion is that the lower bounds tend to be substantially larger than P-values, raising serious questions concerning the routine use of...