Introduction Initiation of antiretroviral therapy (ART) and co-trimoxazole preventive therapy (CPT) is recommended for tuberculosis (TB)/human immunodeficiency virus (HIV) co-infected patients to prevent opportunistic infection. The aim of this study was to assess the prevalence of HIV among TB patients and initiation of ART and provision of CPT for TB/HIV co-infected patients in Hawassa univer...

BACKGROUND High HIV burden countries have experienced a high burden of pleural TB in HIV-infected patients. OBJECTIVE To review the epidemiology, immunopathogenesis, diagnosis, and treatment of pleural TB in HIV-infected patients. METHODS A literature search from 1950 to June 2011 in MEDLINE was conducted. RESULTS Two-hundred and ninety-nine studies were identified, of which 30 met the in...

INTRODUCTION South Africa has the highest reported rates of multi-drug resistant TB in Africa, typified by poor treatment outcomes, attributable mainly to high default and death rates. Concomitant HIV has become the strongest predictor of death among MDR-TB patients, while anti-retroviral therapy (ART) has dramatically reduced mortality. TB Case fatality rate (CFR) is an indicator that specific...

BACKGROUND The objective of the study was to assess the implementation and the performance of recommended collaborative TB/HIV activities in Batibo District Hospital (BDH) and to determine the prevalence of HIV in TB patients in this rural locality. METHODS The implementation of collaborative TB/HIV activities was assessed through interviews with health workers in the hospital. The implementa...

BACKGROUND While the risk of TB is elevated in HIV-positive subjects with low CD4 cell counts, TB may in itself be associated with CD4 lymphocytopenia. We investigated markers of immune activation (neopterin) and inflammation (CRP) in TB patients with and without HIV coinfection and their association with CD4 cell levels, and determined their predictive capacity as alternative markers of advanc...

conclusions in cd4 positive cell count below 500, the dominant radiographic pattern of tuberculosis is atypical presentation. at this level of immunity, cd 4 positive t cell dysfunction may play a deterministic role in tb radiographic manifestation. results of a total 15 patients (86.7% men and 13.3% women), 78.6% had cd4 positive counts below 350 (mean ± sd; 229.15 ± 199.45). the most common r...

BACKGROUND The aim of this study was to describe risk factors for mortality and clinical characteristics of HIV-infected patients with and without tuberculosis (TB) coinfection. METHODS A cohort of HIV-infected patients with CD4(+) T-cell counts of ≤200 cells/μl was recruited, consisting of 255 HIV-infected patients without active TB and 231 patients with active TB. All received a well-superv...

OBJECTIVE To explore the potential impact of enhanced tuberculosis (TB) diagnostic techniques as a TB control strategy in an adult population with high HIV prevalence. DESIGN A compartmental difference-equation model of TB/HIV was developed using parameter estimates from the literature. METHODS The impact of five TB control interventions (rapid molecular testing, mycobacterial culture, comm...

BACKGROUND Little is known about the prevalence of tuberculosis (TB) and HIV among TB suspects in primary health care units in Ethiopia. METHODS In the period of February to March, 2009, a cross sectional survey was done in 27 health centers of Addis Ababa to assess the prevalence of TB and HIV among TB suspects who have > = 2 weeks symptoms of TB such as cough, fever and weight loss. Diagnos...

OBJECTIVE To evaluate an enzyme-linked immunospot assay (ELISPOT) for the diagnosis of tuberculosis (TB) in HIV-infected children with suspected TB and to compare the performance of ELISPOT with the tuberculin skin test (TST). METHODS Interferon-gamma responses to Mycobacterium tuberculosis-specific antigens were measured by ELISPOT in HIV-infected children with suspected TB. HIV-infected and...