Disruptions in sleep-wake cycles are particularly prevalent after a Traumatic Brain Injury (TBI). Sleep disruptions may occur as main impact of brain damage or result other neuropsychiatric sequelae TBI, such anxiety disorder, depressive disorders, substance abuse, chronic pain, and/or medication consumption. Chronic discomfort (headache and broad presumably central origin) sleep difficulties (...

Fifty-one children between 26 and 214 months of age (median, 100 months) with acute lymphoblastic leukemia (ALL) were grafted in second remission from HLA-identical sibling donors (except for two patients who were grafted with a marrow with 1 antigen-mismatch). Initial treatment and relapse therapy were similar in all patients according to the BFM- and CoALL-protocols (front line: 38 patients a...

Allogeneic bone marrow transplantation (BMT) remains the treatment of choice for a number of malignant conditions. Much of the therapeutic potential of this procedure for these diseases relates to the graft-versusleukemia (GVL) effect, which eradicates host malignancy after BMT and is mediated by donor T and natural killer (NK) cells (1). GVL effects are closely associated, however, with graft-...

conclusions a long-term longitudinal study encompassing integrated research is needed to fully understand the traumatic experiences of caregivers. unless research on tbi or dai trauma is given its proper attention, the burden of trauma and injury on societies will continue to exacerbate globally. context as with care giving and rehabilitation in chronic illnesses, the concern with traumatic bra...

objective: following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (icp), and nerve damage. the current study assessed the effects of aqueous date fruit extract (adfe) on the aforementioned parameters. materials and methods: in this experimental study, diffused traumatic brain injury ...

Insulin-like growth factors (IGF) are potent neurotrophic and neurorepair that were recently proposed as biomarkers of traumatic brain injury (TBI) associated psychiatric comorbidities, in particular post-traumatic stress disorder (PSTD). We tested the hypothesis IGF system is differentially deregulated acute early chronic stages TBI, under stress. Plasma IGF1 IGF2 levels evaluated mice 3 weeks...

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and many survivors experience a wide range of neurological impairments after TBI. Following the initial mechanical injury at the moment of a TBI event, various cellular and molecular processes are activated as the secondary injury. Neuroinflammation is an important mechanism involved in the secondary injury of TBI...

Traumatic brain injury (TBI) is a common cause of death which affects millions of people around the world. TBI is also associated with various neurological impairments. After the primary mechanical injury at the moment of a TBI event, several cellular and molecular processes are activated within the brain tissue as the secondary injury. An important mechanism involved in the secondary injury of...