Transient depolarizations (TDs) appeared in canine Purkinje tissue but not in cardiac muscle during exposure to 1-2 X 10~ g/ml of acetylstrophanthidin. At low levels of toxicity, the TDs were associated with a decrease in threshold and an increase in automaticity. As intoxication progressed, the TDs coincided with transient periods of increased threshold and conduction block. Propagation from m...

In this paper we consider test statistics based on individual genotyping. For sibships without parents, but with unaffected as well as affected sibs, we introduce a new test statistic (referred to as TDS), which contrasts the allele frequency in affected sibs versus that estimated for the parents from the entire sibship. For sibships without parents, this test is analogous to the TDT and is com...

Bangalore city hosts two Urban Wastewater Treatment Plants (UWTPs) towards the periphery of Vrishabhavathi valley, located in Nellakedaranahalli village of Nagasandra and Mailasandra Village, Karnataka, India. These plants are designed and constructed with an aim to manage wastewater so as to minimize and/or remove organic matter, solids, nutrients, disease-causing organisms and other pollutant...

The testicular dysgenesis syndrome (TDS) hypothesis proposes that maldevelopment of the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and consequent downstream TDS disorders. Studies in rats exposed in utero to di(n-butyl) phthalate (DBP) have strongly supported the TDS concept, but so far no direct evidence has been produced that links dysgenesis pe...

Previous studies have indicated that salmonid fertilization success may be very sensitive to elevated concentrations of total dissolved solids (TDS) with effects at concentrations as low as 250mgl(-1) being reported. However, interpretation of these studies is complicated by poor control performance and variable concentration response relationships. To address this, a series of experiments were...

This review addresses whether there is a secular increasing trend in male reproductive developmental disorders (cryptorchidism, hypospadias, testis cancer, low sperm counts), and highlights the limitations of available data and how these issues are being addressed. These disorders are considered to represent a syndrome of disorders [testicular dysgenesis syndrome (TDS)] with a common origin in ...

Eighteen multiparous lactating grazing Holstein cows, 9 ruminally cannulated, average 136.1 +/- 14.6 days in milk, were randomly assigned to three treatments consisting of water containing different levels of total dissolved solids (TDS; mg/l): Treatment 1 = 1,000; Treatment 2 = 5,000 and Treatment 3 = 10,000, at the Experimental Dairy Unit at Rafaela Experimental Station (31 degrees 11'S latit...

Tardive syndromes (TDS) are a group of movement disorders. Tardive dyskinesia is the best-known type of TDS. Another type of TDS is tardive dystonia. TDS cause body parts to move uncontrollably. Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics but occasionally antidepressants (Jankovic 1995). However, tardive dystonia associated with...

Demanding public opinion for providing safe drinking water is now an increasing constant pressure on the authorities concerned to prevent the human health from contaminated drinking water. Hence latest techniques are employed to predict the critical parameters like, pH, chlorine, turbidity, TDS, and Electrical conductivity, in the distribution systems. In this study Radial Basis Function RBF mo...

It has been hypothesized that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the so-called testicular dysgenesis syndrome (TDS). TDS was suggested to be a result of disruption of embryonal programming and gonadal development during foetal life and as aetiological factor, an impact of adverse environmental factors such as hormone disr...