Unrepaired DNA nucleotide lesions, derived from endogenous (radical oxygen species, base decay, etc) or exogenous (sunlight, smoke, alcohol, etc.) sources can compromise cellular and organismal health. Cellular responses to DNA damage range from DNA damage responses (DDR) including checkpoints, senescence 1and apoptosis, to nucleotide substitutions and genomic rearrangements [1]. A common inter...

De novo formation of tertiary lymphoid structures (TLS) has been described in lung cancers. Intratumoral TLS seem to be functional and are associated with a long-term survival for lung cancer patients, suggesting that they represent an activation site for tumor-specific T cells. Here, we characterized T-cell recruitment to TLS in human lung cancer to identify the adhesion molecules and chemoatt...

We study counterintuitive dynamics of a two-level system (TLS) interacting with electric field superoscillating in time. We show that a TLS may be excited by an external light pulse whose spectral components are below the absorption line of the TLS. We attribute this unique dynamics to the Rabi oscillations of the TLS in a superoscillating driving field.

An internet user wanting to share observed content is typically restricted to primitive techniques such as screenshots, web caches or share button-like solutions. These acclaimed proofs, however, are either trivial to falsify or require trust in centralized entities (e.g., search engine caches). This motivates the need for a seamless and standardized internet-wide non-repudiation mechanism, all...

Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform a two-stage siRNA-based functional screen for mammalian TLS genes and identify 17 validated TLS genes. One of the genes, NPM1, is frequen...

This document describes extensions that may be used to add functionality to TLS. It provides both generic extension mechanisms for the TLS handshake client and server hellos, and specific extensions using these generic mechanisms. The extensions may be used by TLS clients and servers. The extensions are backwards compatible communication is possible between TLS 1.0 clients that support the exte...

Above ground biomass (AGB) is a parameter commonly used for assessment of grassland systems. Destructive AGB measurements, although accurate, are time consuming and are not easily undertaken on a repeat basis or over large areas. Structure-from-Motion (SfM) photogrammetry and Terrestrial Laser Scanning (TLS) are two technologies that have the potential to yield precise 3D structural measurement...

Noise performance is one of the most crucial aspects of any detector. Superconducting Microwave Kinetic Inductance Detectors (MKIDs) have an “excess” frequency noise that shows up as a small time dependent jitter of the resonance frequency characterized by the frequency noise power spectrum measured in units of Hz/Hz. Recent studies have shown that this noise almost certainly originates from a ...

Abstract In this study, the dynamics of tendon/top tension riser (TTR) system a tension-leg platform (TLP) are investigated through an experiment and by using absolute nodal coordinate formulation (ANCF). First, model test TLP is conducted in water tank Harbin Engineering University to examine motion response dynamic characteristics tendon TTR. The scale ratio set 1: 66.3. Then, on basis ANCF, ...

Chicks initiate bilateral alternating steps several days before hatching and adaptively walk within hours of hatching, but emergence of precocious walking skills is not well understood. One of our aims was to determine whether interactions between environment and movement experience prior to hatching are instrumental in establishing precocious motor skills. However, physiological evidence of pr...