PURPOSE The α1-adrenoreceptor antagonists, such as terazosin and doxazosin, induce prostate programmed cell death (apoptosis) within prostate epithelial and stromal cells in vitro. This treatment should cause prostate volume decrease, However, this has never been observed in clinical conditions. The aim of this paper is to review the disconnect between these two processes. METHODS PubMed and ...

Resistant hypertension is a common and refractory complication of hemodialysis (HD) patients and is associated with a higher risk of cardiovascular morbidity and mortality. Here we present a case of resistant hypertension treated successfully by nocturnal HD. A 63-year-old female with end-stage kidney disease was hospitalized for severe headache, objective vertigo and persistent vomiting for 1 ...

BACKGROUND The alpha1-adrenoceptor-blocking antihypertensive doxazosin has been associated with increased risk of heart failure and is known to induce prostate cell apoptosis. We hypothesized that it might also induce apoptosis in cardiomyocytes. METHODS AND RESULTS Hoechst dye vital staining and flow cytometry provided evidence that doxazosin induced apoptosis time- and dose-dependently in c...

A 78-year-old male with a history of hypertension for 7 years, on regular treatment, with paroxysmal atrial fibrillation and hyperlipidemia was admitted into the urologic ward in June 2000 because of acute urine retention secondary to benign prostate hyperplasia (BPH). His usual medication included metoprolol, simvastatin and perindopril, which was changed to candesartan after admission. His se...

PURPOSE Preoperative preparation for adrenalectomy for pheochromocytomas and paragangliomas (PPGL) is universally recognized as necessary, while the optimal strategy remains controversial. Our aims were to increase intraoperative hemodynamic stability, expedite postoperative recovery, decrease side effects and reduce costs for patients with PPGL undergoing adrenalectomy. METHODS We identified...

Since intraoperative floppy iris syndrome (IFIS) was first described in 2005, its association with the systemic alpha-1 adrenergic antagonist, tamsulosin (Flomax®, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT), has become well established [1-7]. The clinical manifestations of IFIS complicating cataract surgery are poor preoperative pupil dilation, iris billowing and prolapse, and ...

Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor neuron (SMN) protein. One remarkable, yet unresolved, feature of SMA is that not all motor neurons are equally affected, with some populations displaying a robust resistance to the disease. Here, we demonstrate that ...

OBJECTIVES A randomised controlled trial was performed to compare the symptomatic effects on patients with benign prostatic hyperplasia (BPH) treated by two therapeutic approaches - the Western medicine (WM) and traditional Chinese medicine (TCM). METHODS Four primary outcome measures, namely the quality of life (QOL), maximum urine flow ratio (UFR), International Prostate Symptom Score (IPSS...

Previous Conclusions and Recommendation:  Evidence does not support a difference in efficacy/effectiveness  Evidence does not support a difference in harms/adverse events  Tadalfil demonstrated improvements in urinary symptoms compared to placebo in patients with lower urinary tract symptoms, but demonstrated no difference in post void residual volume or urinary flow rate.  Tadalafil is als...

Background & Aims: [alpha]1-Adrenergic blockers have recently been shown to increase the rate of spontaneous passage of distal urethral stones. In this study the clinical role of Terazocin and Prednisolone in expulsion therapy of symptomatic distal urethral stones was assessed. Methods: The total number of 106 patients between 20-68 years old (Mean 39.05 years) who had lower ureteral stones wit...