On 1 January 1996, diphtheria-tetanus revaccination at the age of 5 years was implemented in the Danish Childhood Vaccination Programme. Initially, a combined DT vaccine containing 25 Lf diphtheria toxoid was used. Due to a high frequency of spontaneously reported adverse reactions, however, concerns were raised that the diphtheria dose was too high, and it was reduced to 6.25 Lf. This survey p...

introduction: gp63 is a major surface protease of leishmania promastigotes that plays an important role in its virulance. as gp63 on its own can not develop an effective protection against leishmaniasis, the goal of this study was to evaluate the protective effect of gp63 conjugated with tetanus toxoid (tt) and vitamin d3 in susceptible balb/c mice against cutaneous leishmaniasis. methods: this...

Natural polymer like potato starch is a mixture of amylose and amylopectin, . Extraction of Potato starch was performed by rasping, centrifugation, refining and drying method. In our research method, we employed potato starch as a biodegradable polymer; It has a great impact on pharmaceutical applications due to its bioavailability, non toxic, high change density and biodegradability. In our re...

The various guidelines for the administration of tetanus toxoid and antitetanus immunoglobulin are not only complicated, but also have never been supported by any scientific experimental studies. This study has measured the antibody levels in a random sample of 157 patients presenting to an accident and emergency department. Levels were measured before and after boosting doses. The results show...

INTRODUCTION Bull horn injuries are severe lesions with a high risk of bacterial contamination, and are common in countries where people are fond of bullfighting and related spectacles. CASE REPORT A 19-year-old man was referred with a penetrating wound in the superior left eyelid produced by a bull horn and resulting in a fracture of the orbital roof and a fat hernia. Prophylactic antibiotic...

BACKGROUND Diphtheria and tetanus toxoid combined with acellular pertussis (DTaP) vaccines are less reactogenic than diphtheria and tetanus toxoid combined with whole cell pertussis (DTwP) vaccines. However, local reactions increase in rate and severity with each successive DTaP dose, and swelling of the entire injected limb has been reported after booster doses. METHODS We reviewed reports o...

Vaccinations are recommended throughout life to prevent vaccine-preventable diseases and their sequelae. Adult vaccination coverage, however, remains low for most routinely recommended vaccines and well below Healthy People 2020 targets. In October 2012, the Advisory Committee on Immunization Practices (ACIP) approved the adult immunization schedule for 2013. Apart from influenza vaccination, w...

A collaborative study has been performed to validate two in vitro serological assays, ELISA and ToBI test, as alternatives to the direct challenge procedure for potency testing of tetanus toxoid vaccines for human use (Ph.Eur. monograph Tetanus vaccine (adsorbed) (0452)). In six laboratories, guinea-pigs were immunised with tetanus toxoid vaccines from different manufacturers representing vario...