The combination of 1-hydroxy-tetrazole and 1-hydroxy-1,2,4-triazole produces a new bisheterocyclic moiety, which is characterized derivatized extensively. We tried to combine the positive advantages TKX-50 MAD-X1 backbone with this building block.

1,1,3,3-Tetra(1H-tetrazol-5-yl)propane-based energetic salts were synthesized in a simple and straightforward manner. The structures of these new salts were determined by (1)H and (13)C NMR spectroscopy, IR spectroscopy, MS, and elemental analysis. All of these compounds showed good thermal stabilities above 180 °C, as confirmed by thermogravimetric-differential thermal analysis (TG-DTA) measur...

The selectively (15)N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with (15)N-labeled nitrous acid. The synthesized compounds were studied by (1)H, (13)C, and (15)N NMR spectroscopy in DMSO, TFA, and DMSO/TFA solutions, where the azide-tetrazole equilibrium could lead to the formation of two tetrazoles (T, T') and one azide (A) isomer for...

Protein arginine deiminases (PADs) catalyze the post-translational hydrolysis of arginine residues to form citrulline. This once obscure modification is now known to play a key role in the etiology of multiple autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, lupus, and ulcerative colitis) and in some forms of cancer. Among the five human PADs (PAD1, -2, -3, -4, and -6), it i...

The multifunctional ‘insect kinins’ share the evolutionarily conserved C-terminal pentapeptide motif Phe-X-X-Trp-Gly-NH2, where X 1 = His, Asn, Ser, or Tyr and X = Ser, Pro, or Ala; and are associated with the regulation of diuresis in a variety of species of insects. We previously reported the functional expression of a southern cattle tick (Boophilus microplus) G protein-coupled receptor that...

A T-jump/time-of-flight mass spectrometer (T-Jump/TOFMS) is used to probe the decomposition of several aminotetrazole containing energetic materials under very high heating rates of 10(5)-10(6) K/s. The materials investigated are 5-amino-1-methyl-1H-tetrazolium dinitramide (MeHAT_DN), 1,5-diamino-4-methyl-1H-tetrazolium dinitramide (MeDAT_DN), 1,5-diamino-1H-tetrazolium nitrate (DAT_N), 1,5-dia...