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تعداد نتایج: 459 فیلتر نتایج به سال:
Epithelial–mesenchymal transition (EMT) is a normal developmental program that is considered to also play an important role in cancer metastasis. Ultimate inducers of EMT are transcriptional repressors that individually can induce experimental EMT, yet in many cells, particularly cancer cells, multiple inducers are expressed simultaneously.Why, and if, and how they interact to regulate EMT is u...
Loeys-Dietz syndrome (LDS) is a rare autosomal dominant disease related to genetic mutations in receptors for the cytokine transforming growth factor-receptor type 1 (TGFB-R1) or 2 gene (TGFB-R2) on the cell surface. LDS results in abnormal protein synthesis and dysfunctional connective tissue, which can result in unique cardiovascular anesthesia challenges related to perioperative management. ...
Tumor cell survival in the hostile distant organ is a ratelimiting step in cancer metastasis. Bone marrow–derived myeloid cells can form a premetastatic niche and provide a tumorpromoting microenvironment. However, it is unclear whether these myeloid cells in the premetastatic site have any direct effect on tumor cell survival. Here, we report that chemokine CCL9 was highly induced in Gr-1þCD11...
Abstract A proper balance of pro and anti-inflammatory cytokines at the fetal-maternal interface is crucial for successful embryo implantation placental formation (placentation) during early gestation. However, mechanisms controlling this inflammatory profile are not well characterized. The C-X-C motif chemokine ligand 12 (CXCL12) its receptor CXCR4 expressed by fetal maternal tissues implicate...
When tissues are injured, vasodilation of capillaries and extravasation of plasma proteins into the interstitial tissue mark the onset of vascular remodeling following tissue assault (Bhushan et al., 2002). These processes are crucial not only for initiating a healing response, but also for enabling re-establishment of tissue homeostasis. Although molecules that regulate aspects of vascular sta...
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