Sir, Severe, chronic, recurrent erythema nodosum leprosum (ENL) is a serious problem. Patients are in need of effective and safe treatment because there is a danger of steroid dependence. Thalidomide has been shown to be highly effective in the treatment of refractory ENLs.[1] A number of dosage regimens of thalidomide, an expensive drug, have been tried.[1-3] We describe our experience of the ...

INTRODUCTION ENL (4–6). However, there was no explanation for the mode of action of thalidomide in lepra reactions. In the early 1980s, with the increasing understandSince the synthesis of thalidomide (a-N-phthalimiing of the roles of particular cells in the developing doglutarimide) by Kunz and others in 1956 (1) for use immune response, it became clear that some diseases as a sedative, no dru...

Over the years, thalidomide has been prescribed for an increasing number of diseases, including multiple myeloma and erythema nodosum leprosum. In Brazil and other countries, thalidomide is available in tablets, and there is no official dissolution testing available for this dosage form. Considering this, a dissolution method was developed and validated for tablets containing 100 mg of each pol...

Introduction. Immunomodulatory drugs (IMiDs) are a class of chemical derivatives thalidomide with numerous immunomodulatory, antiangiogenic, anti-inflammatory, and cytostatic effects in multiple myeloma (MM). Aim — to highlight the history discovery IMiDs discuss molecular mechanisms their therapeutic activity. Basic information. In 2010, more than half century after German company Chemie Grüne...

Thalidomide is a tumor necrosis factor alpha (TNFα) inhibitor which has been found to have abilities against tumor growth, angiogenesis and inflammation. Recently, it has been applied in clinic for the treatment of multiple myeloma as well as some inflammatory diseases. However, whether thalidomide has any therapeutic effects on neurodegenerative disorders, i.e. Alzheimer's disease (AD) is not ...

Thalidomide has one of the most notorious drug histories because of its teratogenicity. Its widespread use in the 1960s led to a worldwide epidemic of phocomelia in inborns; this in turn led to its complete ban in most of the world. However, it has now been licensed for selected indications including graft-versus-host-disease (GVHD) after bone marrow transplantation, wasting associated with tub...

We report a multicenter, randomized phase II trial conducted to assess the tolerability of combined thalidomide and prednisone maintenance in multiple myeloma. Eligibility required administration of melphalan (200 mg/m2) with blood stem cell support within 1 year of treatment onset and initiation of maintenance within 60 to 100 days after stem cell infusion. All patients received 50 mg of predn...

OBJECTIVES 40 years ago, the sudden increase of births of babies with a range of severe deformities shocked the world. It was caused by the tranquilizer thalidomide. Women who took the drug in the first trimester of pregnancy gave birth to children with a wide but distinctive range of malformations. Thalidomide claimed more than 10,000 victims worldwide. Those who survived are now reaching midd...

CONTEXT Sixty-five percent of people with advanced cancer suffers from loss of appetite. Several inflammatory cytokines appear to cause appetite loss in animal models. Thalidomide is an immunomodulatory drug that has been associated with improved appetite in those with HIV infections and cancer. OBJECTIVES We completed a two-stage Phase II dose titration study of thalidomide, the primary purp...

OBJECTIVE: The current meta-analysis was carried out to identify the efficacy and safety of thalidomide in transfusion-dependent β-thalassemia (TDT) patients. METHODS: Six databases: PubMed, EMBASE, Scopus, Cochrane Library, EBSCOhost, MEDLINE were searched until November 18, 2021, for studies that assessed TDT patients by using following search terms: “Thalidomide”, “thalidomid”, “thalomid”, “...