Superoxide dismutase (SOD) fusion of TAT was proved to be radioprotective in our previous work. On that basis, a bifunctional recombinant protein which was the fusion of glutathione S-transferase (GST), SOD, and TAT was constructed and named GST-TAT-SOD. Herein we report the investigation of the cytotoxicity, cell-penetrating activity, and in vitro radioprotective effect of GST-TAT-SOD compared...

One commonly asked question when confronted with a photograph is “Where is this place?” When talking about a place mentioned on the Web, the question arises “What does this place look like?” Today, these questions can not reliably be answered for Web images as they typically do not explicitly reveal their relationship to an actual geographic position. Analysis of the keywords surrounding the im...

Objective—The region of the 110 kDa regulatory subunit (MYPT1) of smooth muscle myosin phosphatase involved in the regulation of contraction was determined under physiological conditions. Methods and Results—Using HIV Tat protein-mediated protein transduction, the N-terminal fragments of MYPT1 were introduced to the intact porcine coronary arterial strips. Pre-incubation with 3 mol/L TAT-MYPT1,...

OBJECTIVE To generate consensus gene expression profiles of invasive breast tumors from a small cohort of Saudi females, and to explore the possibility that they may be broadly conserved between Caucasian and Middle Eastern populations. METHODS This study was performed at King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia, from January 2005 to January 2007. G...

Letter by Zuo and Xu Regarding Article, “Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats” To the Editor: We read with interest the recent study by Zhou et al titled “Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats.” The authors performed a study to investigate a potential role and mechanism of Tat-HA-NR2B9c in the subacute phase afte...

BACKGROUND Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that has effects on wounding healing and neuro-protection. However, it is difficult to use bFGF to treat diseases that are separated by physiological barriers, such as the dermal barrier and blood brain barrier. METHODOLOGY/PRINCIPAL FINDINGS To improve bFGF's penetration ability, we fused the ...

Abdominal obesity describes the accumulation of excessive fat in the abdomen. It is known that depending on its distribution, visceral obesity presents a greater danger to health than subcutaneous obesity. To properly prevent and treat visceral obesity, accurate evaluation methods are necessary, and hence quantitative VAT estimation is extremely important. CT scans are the most accurate method ...

The data reported here were gathered in the course of a study of personalities of research scientists as related to vocation The 64 subjects of that study are eminent research scientists in the fields of biology, physics and physical chemistry, psychology and anthropology Most of the men are members of the National Academy of Sciences, or the American Philosophical Society, or both Age range is...