The natural products epothilone and bleomycin are assembled by hybrid polyketide/nonribosomal peptide synthetases. Of note in these assembly lines is the conversion of internal cysteine residues into thiazolines and their subsequent oxidation to heteroaromatic thiazole rings. We have excised the EpoB oxidase domain, EpoB-Ox, proposed to be responsible for thiazoline to thiazole oxidation in epo...

Background and objective: Six families of thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine are new and important heterocyclic antibacterial compounds. Aim of this study is evalution the antibacterial effect of thirty new thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine derivatives against Bacillus subtilis and salmonella ente...

A variety of logic operations such as XNOR, NOR, AND, NAND, NOT have been designed with pH as an external modulator by choosing thiazole orange (TO) and a c-kit2 promoter quadruplex as two inputs and fluorescence signals of pyridyl bis-indole amide (PBIA) and TO as two outputs.

imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate.  these imidazo[2,1-b]thiazoles in the presence of p-tsa in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

background: schizophrenia has been associated with altered immunity. different studies regarding natural killer cell activity (nka) in schizophrenic patients have shown inconsistent results. objectives: to evaluate nk cell activity in schizophrenic patients in comparison with healthy control individuals.   methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...