Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several alpha-bromocarbonyl compounds gave new 2-(E)-...

A series of novel N-[2-(substituted phenyl)-5-methyl-4-oxo-1,3-thiazolidin-3-yl]benzamides (4a-g) were synthesized, structurally confirmed by elemental analysis, IR, H NMR and MS spectral analysis, further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cells infected with wildtype HIV-1 strain IIIB and HIV-2 strain ROD in comparison with nevirapine (NVP), azidothymidine (AZT), d...

1-(Acridin-9-yl)-3-disubstituted thioureas react with methyl bromoacetate and bromoacetonitrile, respectively, depending on a substituent bulkiness, to polyfunctionally substituted (acridin9-yl)imino-1,3-thiazolidin-4-ones and spiro[9,10-dihydroacridine-9,4-thiazolidines]. Reactions represent the simple and convenient way to synthesize the title compounds with possible antibacterial activity. B...