New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to examine the correlation between anticancer activity and cholinesterases, the compounds were evaluated for their inhibitory effects on AChE and BuChE. The most effective anticance...

BACKGROUND Adverse antimicrobial activities of thiosemicarbazone (TSC) and Schiff base derivatives have widely been studied by using different kinds of microbes, in addition different methods were used to assay the antioxidant activities using DPPH, peroxids, or ntrosyl methods. However, there are no studies describing the synthesis of TSC derived from creatinine. RESULTS In this study, 2-(2-...

Pyromellitic dianhydride 1 was used as starting compound for the synthesis of some new derivatives of condensed dipyrrole, dibenzoxazine, and dipyridazine. Thus, the diimide 2 was formed on fusion of 1 with urea, thiourea and/or thiosemicarbazide. Also, 1 reacted with benzylamine to give terephthalic acid derivative 3 which on fusion afforded the cyclic diimide 4. The reaction of 1 with o-amino...

The in vitro antifungal potency of six series of 4-arylthiosemicarbazides was evaluated. Two isoquinoline derivatives with an ortho-methoxy or ortho-methyl group at the phenyl ring were the most potent antifungal agents. Molecular modeling studies and docking of all 4-arylthiosemicarbazides into the active sites of sterol 14α-demethylase (CYP51), topoisomerase II (topo II), L: -glutamine: D: -f...