BACKGROUND Testing for clustering at multiple ranges within a single dataset is a common practice in spatial epidemiology. It is not documented whether this approach has an impact on the type 1 error rate. METHODS We estimated the family-wise error rate (FWE) for the difference in Ripley's K functions test, when testing at an increasing number of ranges at an alpha-level of 0.05. Case and con...

Wisdom is recognisable for its facets of fair judgment, experience, carefulness, and compassion—but also a degree of risk taking. The wise people I knowmake choices that are based on likely consequences. They consider all options but are also decisive. They are fair minded, having little ego to get in the way of what might be best for others. Wise people make good role models, although they mos...

t is a generally accepted fact that higher education is one of America’s shining achievements. Since the GI Bill, U.S. higher education has created the largest middle class in the history of the world, and it is arguably American’s most popular export. Students from all over the world seek higher education in the U.S. Although the general public perceives the price of American higher education ...

The existence of different auxin sensitivities in epidermal and subepidermal tissues (KV Thimann, CL Schneider 1938 Plant Physiol 25: 627-641) suggests a refinement to the Cholodny-Went theory which overcomes some of the difficulties associated with it. A model is presented to account for the inverse tropic responses of shoots and roots through differences in the respective locations of the aux...

Guillermo Lorenzo Departamento de Filologı́a Española Universidad de Oviedo Oviedo, Spain [email protected] Abstract In this article we offer a detailed assessment of current approaches to the origins of language, with a special focus on their historical and theoretical underpinnings. It is a widely accepted view within evolutionary linguistics that an account of the emergence of human language...

Agile development methods continue to enjoy widespread use, with more and more companies transitioning to agile methods. Current literature suggests that most of those companies are successful in making the transition, but others are not so successful. This paper examines one such company – referred to within as the ‘ABC Company’ to maintain their privacy – and analyzes and discusses their stru...

ayn al qodat hamadani has created a unified thought system through jamal and jalal and the dialectic between them. it is impossible to perceive his mindset without a deep understanding of this thought system. this maqian hakim relies so heavily on this duality and other dualities that jumping to conclusions while studying his thought might mislead us to think that he is dualistic. jalal and its...

In the 13th years of prophecy, Prophet Muhammad PBUH along with 75 followers him went to Yastrib, later turned Medina City. The people Yastrib who yearned for wise leader than asked SAW became their leader. Later, established Charter which legal foundation governance in Yastrib. confirmed principles community such as tolerance, brotherhood, amr ma’ruf nahi munkar, equality, discussion, justice ...

Two general classes of multiple decision functions, where each member of the first class strongly controls the family-wise error rate (FWER), while each member of the second class strongly controls the false discovery rate (FDR), are described. These classes offer the possibility that optimal multiple decision functions with respect to a pre-specified Type II error criterion, such as the missed...

In phase II platform trials, 'many-to-one' comparisons are performed when K experimental treatments are compared with a common control to identify the most promising treatment(s) to be selected for Phase III trials. However, when sample sizes are limited, such as when the disease of interest is rare, only a single Phase II/III trial addressing both treatment selection and confirmatory efficacy ...