A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate t...

Advancements in computers, prototyping, and imaging, especially over the last 10 years, have permitted the adoption of three-dimensional imaging protocols in the health care field. In this article, the authors present an integrated simulation system for craniofacial surgical planning and treatment. Image fusion technology, which involves combining different imaging modalities, was utilized to c...

Over the past two to three decades echocardiography has come a considerable distance from the early M-mode machines, and has become an indispensable diagnostic tool in any cardiovascular department. It has long been proved to be safe and cost-effective, and its clinical versatility has steadily increased with the continued integration of newer techniques, such as two-dimensional and harmonic im...

The U.S. Army Night Vision and Electronic Sensors Directorate (NVESD) and the U.S. Army Research Laboratory have developed a terahertz (THz) -band imaging system performance model for detection and identification of concealed weaponry. The MATLAB-based model accounts for the effects of all critical sensor and display components and for the effects of atmospheric attenuation, concealment materia...

In a recent paper a new technique was proposed for remote ranging and topographical mapping by using a system with a single-photon-counting detector and a low-power pulsed laser [Appl. Opt. 35, 441 (1996)]. We report on the results from the laboratory and the field demonstration of this literal three-dimensional imaging technique. Using a detector system developed at Los Alamos with a commercia...

In this paper, we confirm the feasibility of circular SAR images using real SAR data in both modes: two-dimensional imaging for different view angles, or three dimensional imaging mode. This new imaging possibility demonstrates clearly the strong anisotropic behavior of the main scatterers at X-band. This proves both the limitations of the autofocus techniques base on tracking on isotropic stro...

We develop and experimentally test a method for three-dimensional imaging of hidden objects in a scattering medium. In our scheme, objects hidden between two biological tissues at different depths from the viewing system are recovered, and their three-dimensional locations are computed. Analogous to a fly's two eyes, two microlens arrays are used to observe the hidden objects from different per...

Mammalian development is a sophisticated program coordinated by a complex set of genetic and physiological factors. Alterations in anatomy or morphology provide intrinsic measures of progress in or deviations from this program. Emerging three-dimensional imaging methods now allow for more sophisticated morphological assessment than ever before, enabling comprehensive phenotyping, visualization ...

The principle of wavelength-scanning digital interference holography is applied to three-dimensional imaging of a small biological specimen. The images are reconstructed from a number of holograms digitally recorded while the wavelengths are varied at regular intervals, and the numerical interference of the multiple three-dimensional hologram fields results in tomographic images with narrow axi...