TIA-1 (T-cell restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translational repression. It mainly interacts with RNA via its second and third RNA recognition motifs (RRMs), with specificity for U-rich sequences directed by RRM2. It has recently been shown that RRM3 also contributes to binding, with preferential binding for C-rich sequences. Here we designe...

BACKGROUND Aortic stiffness and intima-media thickness (IMT) are known to be associated with ischemic stroke. The aim of the present study was to investigate the differences of aortic stiffness and IMT between cerebral infarction (CI) and transient ischemic attack (TIA). METHODS A total of 500 patients with acute stroke were divided into 2 groups: the TIA group (n = 230, 62.4 ± 12 years, 144 ...

INTRODUCTION Transient ischaemic attack (TIA) is defined by short-lasting, stroke-like symptoms, and is recognised as a medical emergency. Symptoms are assumed to completely resolve, and treatment is focused on secondary stroke/TIA prevention. However, evidence suggests that patients with TIA may experience ongoing residual impairments, which they do not receive therapy for as standard practice...

To evaluate risk factors and prognosis of transient global amnesia (TGA), three groups of 30 subjects each affected respectively by: (1) first-ever TGA; (2) first-ever transient ischaemic attack (TIA); (3) depressive neurosis, were compared. Prevalence of cerebrovascular risk factors was similar in patients with TGA and TIA, but significantly lower in the third group. CT showed more hypodense l...

Research on infarct detection by noncontrast cranial computed tomography (CCT) in patients with transient ischemic attack (TIA) is sparse. However, the aims of this study are to determine the frequency of new infarcts in patients with TIA, to evaluate the independent predictors of infarct detection, and to investigate the association between a new infarct and early short-term risk of stroke dur...

Ninety one patients with stroke or transient ischemic attack (TIA) were screened for sleep-disordered breathing (SDB). Case fatality, rate of recurrence of cerebrovascular events, and functional outcome were analyzed during a 2-year follow-up. The patients were stratified into groups: without (AH < or =5) and with SDB (AHI >5). SDB was present in 61 (67.7%) patients with stroke or TIA. The rate...

After a stroke or transient ischaemic attack (TIA) there is a high risk of stroke, particularly in the early days and weeks, and of other serious vascular events. Several preventive medical treatments can reduce these risks; starting them as early as possible will maximise the absolute risk reduction, as long as the diagnosis is secure, there is no known or suspected net harm from treatment, an...

There have been considerable advances in the management of transient ischaemic attack (TIA) in recent years. It has been proposed that the distinction between TIA and stroke be changed from a time-based to a tissue-based definition [1]. In addition, prospective studies have shown a high risk of stroke within the immediate hours and days after TIA [2]; prognostic scores have been developed to id...

This paper describes a method of extending the signal frequency bandwidth while increasing the stability of a CMOS transimpedance amplifier (TIA). The TIA consists of three inverting amplifiers in a series, and a high-pass filter plus a non-inverting amplifier that are connected to the last two inverting amplifiers stated above in parallel. The TIA is fabricated using a 0.35 μm CMOS process and...

Over the last decade, a number of advances in the care of stroke and TIA patients have been made. These advances include prevention, acute management, and recovery. Some of this work has occurred in Rhode Island. This review will focus on the revised definition of stroke and TIA; short-term risk of TIA; rapid management of TIA; targeted use of medication and lifestyle changes; monitoring for at...