The tissue inhibitors of metalloproteinases 1-4 (TIMPs) have discrete regulatory roles in the activation of matrix metalloproteinase (MMP)-2 (gelatinase A), an important basement membrane-degrading MMP pivotal to tumor metastasis and angiogenesis. TIMP-2 binds to both the hemopexin C domain of progelatinase A and the active site of membrane type-1 (MT1) MMP. This trimeric complex presents the c...

BACKGROUND Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a major role in the maintenance of extracellular matrix homeostasis and are involved in the process of tumour invasion and metastasis in several malignant tumour entities. The goal of this study is to evaluate the diagnostic value of various circulating MMPs and TIMPs in blood plasma for a non-invasive detection of tr...

We have developed a new blend of plant extract obtained from novel two-step fermentation process, the goal current work was to evaluate skin benefits this activein vitro and ex vivo. The antioxidant effect evaluated through Total Antioxidant Capacity assay kit, in performed by treating normal human dermal fibroblasts with 1.5% double ferment mixture for 48 hours, effects on gene expression were...

Objective: It is well established that inherited chromosomal alterations such as copy number variations (CNVs) are associated to miscarriage. However, most studies focus on evaluating CNVs only in products of conception. The aim this systematic review was highlight the importance investigating couples with a history recurrent miscarriage their role pregnancy, filling part gap between Methods: A...

Glioblastoma multiforme (GBM) is one of the most common brain tumors. Chemotherapy, radiotherapy and surgical resection are methods used in GBM treatment, however, investigation possible anticancer effects low-toxicity natural products on various cancer cells, including GBM, leads to promising results. In this study, it was aimed investigate effect tomentosin, which a sesquiterpene lactone, U87...