In the last two decades, anatomic compartmentalization of T and B cells within lymphoid tissues has been demonstrated in a wide variety of species, including man (1-5). T cells are located in the paracortical or interfollicular regions of lymph nodes and in the lymphoid tissues of the intestine and tonsil, whereas in the spleen, T cells are found primarily in the periarteriolar region of the Ma...

During early neurogenesis, the floor plate plays an essential role(s) in the differentiation of the ventral portion of neural tube. In this study, we detected the specific distribution of unique glycoconjugate during the floor plate differentiation. Formalin fixed paraffin sections of BALB/c mice (10-14 embryonic days) were processed for histochemical studies using horseradish peroxidase-labell...

Adipocyte differentiation is a key process implicated in the pathogenesis of obesity and insulin resistance. Its regulation is triggered by a cascade of transcription factors, including the CCAAT/enhancer binding proteins (C/EBPs) and peroxisome proliferator-activated receptor-gamma (PPARgamma). Growth factors such as transforming growth factor-beta1 (TGF-beta1) are known to inhibit adipocyte d...

BACKGROUND In recent years the therapeutic application of extracted adipose tissue for autologous fat grafting and the application of adipose tissue-derived mesenchymal stem cells (adMSC) isolated thereof has progressed. Water-jet assisted liposuction (WAL) is 1 procedure for harvesting adipose tissue and provides a favorable aesthetic outcome combined with high tissue protection. Tissue aspira...

The local mechanical environment is a crucial factor in determining cell and tissue differentiation during vertebrate skeletal development and repair. Unlike the basic response of bone to mechanical load, as described in Wolff's law, the mechanobiological relationship between the local mechanical environment and tissue differentiation influences everything from tissue type and molecular archite...

objective: this study examined the in vivo differentiation of mesenchymal stem cells (mscs) into insulin producing cells (ipcs) on electrospun poly-l-lactide acid (plla) scaffolds coated with matricaria chammomila l. (chamomile) oil. materials and methods: in this interventional, experimental study adipose mscs (amscs) were isolated from 12 adult male new zealand white rabbits and characterized...