The updated international consensus criteria for definite antiphospholipid syndrome (APS) are useful for scientific clinical studies. However, there remains a need for diagnostic criteria for routine clinical use. We audited the results of routine antiphospholipid antibodies (aPLs) in a cohort of 193 consecutive patients with aPL positivity-based testing for lupus anticoagulant (LA), IgG and Ig...

The thesis addresses optimal control problems where the dynamics is given by differential equations with memory. For these optimization problems, optimality conditions are provided; second order conditions constitute an important part of the results of the thesis. In the case – without memory – of ordinary differential equations, standard optimality conditions are strengthened by involving only...

• Permutation tableaux are new objects that come from the enumeration of the totally positive Grassmannian cells [11, 15]. A permutation tableau [12] is a Ferrers diagram together with a filling of the cells with 0’s and 1’s such that the following properties hold: Each column contains at least one 1 and there is no 0 which has a 1 above it in the same column and a 1 to its left in the same row...

Summary The development of alloantibodies (inhibitors) against coagulation factor VIII (FVIII) is the most serious complication FVIII replacement therapy in patients with haemophilia A (HA). We carried out a nationwide study focussing on HA inhibitors China to evaluate condition and management this population. retrospectively analysed patient characteristics, clinical history, manifestation, tr...

RésuméLes discussions contemporaines du concept fécond de forme vie ont permis mettre en évidence à quel point le lui-même est essentiel chez Wittgenstein, structurant la continuité entre premier et second Wittgenstein. En passant « logique » au vie, Wittgenstein entend renoncer une unité pour passer famille structures apparentées. Mais ne disparaît pas – contraire. Le sur lequel...

Introduction THE histopathological studies of Wilder (1952) on eyes removed on account of intractable iritis of unknown origin suggest that toxoplasmosis may have been the cause in some cases. Following on her work, requests were received for the serological investigation of patients suffering from chronic anterior uveitis of undetermined aetiology. Some of these gave weak positive results in t...

background: decay of vaccine–induced antibody titres without boosting of the wild measles virus has been well documented. revaccination against measles has reduced the prevalence of the disease worldwide. revaccination may cause ige induced anaphylaxis. objective: to study measles igg antibody in revaccinated populations and its relation to ige induced hypersensitivity. methods: blood samples w...

OBJECTIVE We developed an assay that detects autoantibodies against the main immunogenic region (MIR) located at the extracellular end of the nicotinic acetylcholine receptor (AChR) α subunit, and investigated its clinical relevance in myasthenia gravis (MG). METHODS In this retrospective cohort study, we measured MIR antibody (Ab) titres in sera obtained before treatment and analysed their a...

The haemolymph JH III titres in solitarious and gregarious adult desert locusts, Schistocerca gregaria, were examined in relation to corpus allatum (CA) volumes, aggregation-maturation pheromone production in males and oocyte growth in females. The JH titres of gregarious females were generally higher than those of solitarious females at all ages studied. The titre patterns, however, were simil...

To estimate susceptibility to the swine-origin influenza A(H3N2) variant virus (A(H3N2)v) in the German population, we investigated cross-reactive antibodies against this virus and factors associated with seroprotective titre using sera from representative health examination surveys of children and adolescents (n = 815, 2003–06) and adults (n = 600, 2008–10). Antibodies were assessed by haemagg...