نتایج جستجو برای: tnfaip3
تعداد نتایج: 403 فیلتر نتایج به سال:
Rickettsia prowazekii, a selective agent of category B, is the causative microorganism of epidemic typhus. The genome-wide profile of host response to R. prowazekii infection was studied in THP-1 cells by a human cDNA microarray. Approximately 131 (1.71%) and 11 (0.14%) genes out of 7,680 genes assessed were up-regulated or down-regulated upon infection with virulent R. prowazekii strain Breinl...
Osteopontin (OPN) is the most upregulated gene in primary central nervous system lymphoma (PCNSL) compared to non-CNS diffuse large B cell lymphoma (DLBCL). We show here that OPN is a key mediator of intracerebral tumor growth, invasion, and dissemination in CNS lymphoma, and that these effects depend upon activation of NF-κB. We further show that activation of NF-κB by OPN occurs through a uni...
Multiple myeloma (MM) is a malignant clonal expansion of plasma cells in the bone marrow and belongs to the mature B-cell neoplams. The pathogenesis of MM is associated with constitutive NF-κB activation. However, genetic alterations causing constitutive NF-κB activation are still incompletely understood. Since A20 (TNFAIP3) is a suppressor of the NF-κB pathway and is frequently inactivated in ...
Retinol dehydrogenase-10 (RDH10) is a member of the short-chain dehydrogenase/reductase family, which plays an important role in retinoic acid (RA) synthesis. Here, we show that RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times. In vitro, lentivirus-mediated shRNA knockdown of RDH10 suppressed glioma cell proliferation, surviva...
A20 (also known as TNFAIP3) is a deubiquitinating enzyme (DUB) that ensures optimal immune responses in cells stimulated by cytokines, such as TNF and IL-1, or pathogen components, such as lipopolysaccharide. Deletion of A20 in mice results in multi-organ inflammation and death within 2 weeks [1]. The anti-inflammatory functions of A20 have been attributed to its ability to negatively regulate ...
Natural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, NKT2, and NKT17 sublineages during development. However, the signaling events that control NKT sublineage specification and differentiation remain poorly understood. Here, we demonstrate that the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an esse...
An autoimmune disorder is an abnormality that causes a disease. It caused by weakened immune system. One of the diseases Sjogren’s syndrome, which affects salivary and lacrimal glands dry mouth, eyes, skin. syndrome influences humans every age, with symptoms occurring at age 45–55 years rarely in children. factors causing genetic disorders. To identify genes can influence this study, we used se...
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