Serotonin syndrome is a neurological disorder primarily associated with inappropriate uses of serotonin (5HT)-promoting drugs such as serotonin reuptake inhibitors (SRIs), monoamine oxidase inhibitors (MAOIs) or 3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) (Boyer et al., 2005; Karunatilake et al., 2006; Parrott, 2002; Paruchuri et al., 2006). The primary cause of the syndrome is due to a g...

Recently, hierarchical state models such as Hare1 statecharts have been vigorously promoted over flat (Mealy-Moore) state models as a panacea for complexity management. Unfortunately, hierarchical state models have a number of severe shortcomings: complex, difficult to learn notation; too many ways of saying the same thing; ill-defined semantics; layers of content-free hierarchy adding to and h...

Designers of e-learning for the workplace face a difficult paradox. On one hand empirical research has established that, in general, providing realistic contexts for new information in a situated environment can enhance formation of the new knowledge in existing schemata. On the other hand, abstractions of subject information, providing overall organization and relationships of new knowledge, h...

Editor's note: Royce Haiman is a freelance writer and former reporter for The St. Petersburg Times. When she told me this story at a social gathering, I suggested she write about it. The entire country—and certainly Baylor University Medical Center—are working now to both avoid wasteful health care spending and increase customer satisfaction. Although the story occurred in Florida, it could eas...

n engl j med 366;2 nejm.org january 12, 2012 178 tive anti-HER2 agents as adjuvant therapies may translate into metastatic disease developing in fewer patients. Given the success of the pivotal trials of adjuvant trastuzumab therapy, clinical trials of adjuvant therapies, which are already large and expensive, will by necessity require even more subjects to detect small differences with a new a...

Fossil-based estimates of diversity and evolutionary dynamics mainly rely on the study of morphological variation. Unfortunately, organism remains are often altered by post-mortem taphonomic processes such as weathering or distortion. Such a loss of information often prevents quantitative multivariate description and statistically-controlled comparisons of extinct species based on morphometric ...

Alcohol use is prevalent in the United States. Given that a substantial portion of the drinking population is of reproductive age, it is not uncommon for couples who are attempting conception, or for women who are already pregnant, to be regularly consuming alcohol. Alcohol use is associated with multiple reproductive risks, including having a child with a Fetal Alcohol Spectrum Disorder, incre...

Our study [1] had two main purposes: first, to examine the occurrence of sleep-disordered breathing (SDB) in patients with chronic fatigue syndrome (CFS), and then to exclude patients with this confound in order to evaluate the structure of sleep in a group of patients with " pure " CFS to look for relations with the symptoms of fatigue and sleepiness. In order to do this, we had to define an u...